Preoperatif Kırmızı Küre Dağılım Genişliği ile Mide Kanseri Ameliyat Sonrası Erken Dönem Ölüm İlişkisi

AMAÇ: Çalışmamızda mide kanserli hastalarda ameliyat öncesi eritrosit dağılım genişliği ölçümünün, postoperatif ilk 30 gündeki erken dönemde mortaliteyi öngörüp göremeyeceğini araştırmayı amaçladık.YÖNTEM: Ocak 2013 ve Kasım 2014 arasında ameliyat edilen mide kanseri olan hastaların kayıtları retrospektif olarak incelendi. 137 hastadan 116 tanesi çalışma için uygun görüldü ve iki gruba ayrıldılar: Grup 1 ameliyat sonrası ilk ay içinde ölenleri içerirken, Grup 2 sağ kalan hastaları içeriyordu.Tanımsal değişkenlere ek olarak, tümör özellikleri ve kırmızı küre dağılım genişliği de gruplar arasında karşılaştırıldı. P değerinin anlamlılığı için

The Relation Between Preoperative Red Cell Distribution Width and Early Postoperative Mortality in Patients with Gastric Cancer

AIM: In our study we aimed to investigate whether the preoperative red cell distribution width measurement can predict the early postoperative mortality within the first 30 days in patients with gastric cancer.METHODS: The records of gastric cancer patients operated between January 2013 and November 2014 were retrospectively analyzed. Of the 137 operations, 116 were eligible for the study and allocated into two groups; Group 1 included the patients died within the first month after operation and Group 2 included the survived patients.Besides the demographics, tumor characteristics and red cell distribution width were compared between groups. P<0.05 was set as the significance level.RESULTS: The median age of the patients was 64. Male/female ratio was 1.9. The tumors were commonly localized at the distal one third of the stomach and most of them were adenocarcinoma.Of the 116 patients, 21 died (Group 1) within the first 30 days of postoperative period. Mean red cell distribution width value in Group 1 was significantly higher than in Group 2 (p:0.002). ROC curve analysis revealed that the cut-off value of 14.75 for red cell distribution width has a sensitivity and specificity of 66.7% and 67.4%, respectively, to predict the early postoperative mortality in gastric cancer patients.CONCLUSION: It seems that the rise in preoperative red cell distribution width can predict the early postoperative mortality in patients diagnosed with gastric cancer.

Kaynakça

1.Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420: 860-7.

2.Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin 2011; 61:69-90.

3. Bertuccio P, Chatenoud L, Levi F, et al. Recent patterns in gastric cancer: a global overview. Int J Cancer 2009; 125: 666-73.

4. Wöhrer SS, Raderer M, Hejna M. Palliative chemotherapy for advanced gastric cancer Ann Oncol 2004; 15: 1585-95.

5. Jatre JP, Meyer HJ. Total gastrectomy in the surgical treatment of primary gastric adenocarcinoma- a 30 year single instution experience. Hepatogastroenterology 2001; 48: 1222-6.

6. Dhar DK, Kubota H, Tachibana M, et al. Body mass index determines the success of lymph node dissection and predicts the outcome of gastric carcinoma patients. Oncology 2000; 59: 18-23.

7. Özgehan G, Kahramanca Ş, Kaya İO, et al. Neutrophillymphocyte ratio as a predictive factor for tumor staging in colorectal cancer. Turk J Med Sci 2014; 44: 365-8.

8. Riedl J, Posch J, Königsbrügge O, et al. Red cell distribution width and other red blood cell parameters in patients with cancer: association with risk of venous thromboembolism and mortality. PLoS One 2014; 9: 1-14.

9. Lee S, Oh SY, Kim SH, et al. Prognostic significance of neutrophil lymphocyte ratio and platelet lymphocyte ratio in advanced gastric cancer patients treated with Folfox Chemotherapy. BMC Cancer 2013, 13: 350-60.

10. England JM, Down MC. Red-cell-volume distribution curves and the measurement of anisocytosis. Lancet 1974; 1: 701-3.

11. Felker GM, Allen LA, Pocock SJ, et al. CHARM Investigators. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007; 50: 40-7.

12. Göçmen E, Kocaoğlu H. Mide kanseri epidemiyolojisi. T Klin J Surg 2000; 5: 161-2.

13. Tuncer İ, Uygan İ, Kösem M, ve ark. Van ve çevresinde görülen üst gastrointestinal sistem kanserlerinin demografik ve histopatolojik özellikleri. Van Tıp Dergisi, 2001: 8; 10-3.

14. Ayar Y, Şahbaz N.A. Bolatkıran Y, et al. Bayburt ilinde yapılan üst gastrointestinal endoskopi sonuçları. Haseki Tıp Bülteni 2013; 51: 116-9.

15. Davis GR. Neoplasms of stomach. In: Sleisenger M, Fordtran JS, eds. Gastrointestinal disease, 5th ed. Philadelphia: WB Saunders 1993: 763-89.

16. Parkin DM. Epidemiology of cancer: Global patterns and trends. Toxicol Lett 1998; 102-103: 227-34.

17. Cox D. R. Regression models and life tables. J R Stat Soc B. 1972; 34: 187-220.

18. Seitanides B, Giakoumakis G, Tsakona C. Increased red cell volume distribution width in patients with bone marrow metastases J Clin Pathol 1988; 41: 1246.

19. Patel KV, Ferrucci L, Ershler WB, et al. Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med 2009; 169: 515-23.

20. Spell DW, Jones DV Jr, Harper WF, et al. The value of a complete blood count in predicting cancer of the colon. Cancer Detect Prev 2004; 28: 37-42.

21. Yilmaz A, Malya F, Ozturk G, et al. Effect of pre-operative red blood cell distribution on cancer stage and morbidity rate in patients with pancreatic cancer. Int J Clin Exp Med 2014; 7: 3072-5.

22. Patel KV,Semba RD,Ferrucci L, et al. Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci 2010; 65: 258-65.

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