Adölesan idiopatik skolyozun patogenezindeki temel teoriler

Adölesan idiopatik skolyozun (AİS) doğal seyri ve tedavisi üzerine çok yol katedilmiş olsa da, oluşumuna neden olan faktörler henüz aydınlatılamamıştır. Birçok araştırma Adölesan idiopatik skolyozun etiyolojisinde nörolojik faktörler, paravertebral kas imbalansı, genetik faktörler, büyüme ve gelişmedeki dengesizlikler, melatonin ve kalmodulin metabolizmasındaki defektler üzerinde durmuştur, ancak bu konuda ortak bir görüş sağlanamamıştır. AİS hastalarında saptanan patolojilerin etiyolojiden sorumlu esas faktör mü olduğu, yoksa deformiteye sekonder gelişen adaptif değişiklikler mi olduğu ayrımı giderek zorlaşmaktadır. Günümüzde insan genom yapısı üzerine olan araştırmalar hız kazanmıştır ve hücre içi biyokimyasal mekanizmalar daha detaylı analiz edilmektedir. Araştırmalar, AİS etiyolojisinde genetik faktörler ve melatonin, kalmodulin metabolizması üzerinde yoğunlaşmaktadır. Multifaktöryel ve karmaşık bir etiyopatogeneze sahip olan AISʼun oluşum ve progresyonundan sorumlu faktör veya fatörlerin aydınlatılması için daha çok araştırma yapılması gerekmektedir. Bu çalışmamızın hedefi AİS etiyopatogenezi üzerine yapılmış araştırmaların derlenmesi, geniş bir perspektiften bakma olanağı sağlamaktır.
Anahtar Kelimeler:

Ergen, Skolyoz

Basic theories in the pathogenesis of adolescent idiopathic scoliosis

Besides considerable accomplishment has been achieved over natural history and treatment of adolescent idiopathic scoliosis, the factors responsible for curve initiation has not been identified yet. Reserchs for causative factors of AIS have focused on neurological factors, paravertebral muscle imbalance, genetic factors, disequilibrium in growth and development, defects in calmodulin and melatonin metabolism, however a consensus has not been provided. In AIS patients discrimination of pathologies whether they are secondary to deformity or causative factor have been increasingly confusing. Researchs related to human genom and intracellular biochemical mechanisms are advancing at present time, and concentrating on genetic factors and melatonin, calmodulin metabolism. As adolescent idiopathic scoliosis has a multifactorial and complex etiopathogenesis, further studies are necessary to enlight factors responsible for initiation and progression of AIS. This review aims to summarize theories and provide a perspective over AIS etiopathogenezis.
Keywords:

Adolescent, Scoliosis,

Kaynakça

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