ASTIM VE KOAH AKUT ATAKLARINDA ELEKTROLİT DENGESİZLİKLERİ
Obstrüktif akciğer hastalıklarının seyrinde elektrolit dengesizliği meydana gelebilmektedir. Bu dengesizlikler havayolu disfonksiyonuna veya solunum kas zayıflığına neden olabilmektedir. Çalışmamızda astım ve kronik obstrüktif akciğer hastalığı (KOAH) akut ataklarında elektrolit profillerini araştırdık. KOAH akut atağı ve solunum yetmezliği olan 35 olgu, astım atağı olan 27 olgu ve pulmoner semptom tanımlamayan enfeksiyon bulgusu olmayan 15 kontrol olgusu çalışmaya dahil edildi. Hastaneye yattıktan sonraki 24 saat içinde sodyum, potasyum, klor, fosfor, magnezyum, arter kanı pH, total ve iyonize kalsiyum, total protein ve albümin düzeyleri ölçüldü. Astım atak olgularının kontrol olgularından daha düşük albümin ve total protein düzeyleri vardı
ELECTROLYTE DISTURBANCES IN EXACERBATIONS OF ASTHMA AND COPD
Electrolyte disturbances can occur in the course of obstructive lung diseases. These anomalies can cause airway dysfunction or respiratory muscle weakness. We investigated electrolyte profiles in asthma attacks and chronic obstructive pulmonary disease (COPD) exacerbations in our study. 35 patients with COPD exacerbations with respiratory failure, 27 patients with asthma attack, and 15 control patients with no infectious findings and pulmonary symptoms included the study. Sodium, potassium, chloride, phosphorus, magnesium, total and ionized calcium, arterial blood pH, total protein, albumin levels were measured within the 24 hours after hospitalization. The patients with asthma attack had lower total protein and albumin levels than controls.
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- 1. Fiaccadori E, Coffrini E, Ronda N, et al.
Hypophosphatemia in course of obstructive
pulmonary disease. Chest 1990; 97: 857-68.
- 2. Gustafson T, Boman K, Rosenhall L, et al. Skeletal
muscle magnesium and potassium in asthmatics
treated with oral beta 2-agonists. Eur Respir J
1996; 9: 237-40.
- 3. Meehan RT. Renin, aldosterone, and vasopressin
responses to hypoxia during 6 hours of mild
exercise. Aviat Space Environ Med 1986; 57: 960-5.
- 4. Burtis CA, Ashwood ER. Tietz textbook of clinical
chemistry, W.B. Saunders Company, 1986.
- 5. Fahy JV, Wong H, Liu J, Boushey HA. Comparison
of samples collected by sputum induction and
bronchoscopy from asthmatic and healthy subjects.
Am J Respir Crit Care Med 1995; 152: 53-8.
- 6. Kushner I, Rzewnicki DL. The acute phase response:
General aspects. Bailliere’s Clin Rheumatol 1994;
8: 513-30.
- 7. Gonlugur U. Eozinofil lökositler, Dilek Ofset Matbaac›l›k,
Sivas, 2001, sayfa:212.
- 8. Kalenci S, Kömürcüo¤lu A, Erer OF ve ark. Kronik
obstrüktif akci¤er hastal›¤›nda plazma ve eritrosit
magnezyum düzeyleri. ‹zmir Gö¤üs Hastanesi
Dergisi 1998; 12: 15-8.
- 9. Ryan MF. The role of magnesium in clinical
biochemistry: an overview. Ann Clin Biochem
1991; 28: 19-26.
- 10. Milionis HJ, Alexandrides GE, Liberopoulos EN, et
al. Hypomagnesemia and concurrent acid-base and
electrolyte abnormalities in patients with congestive
heart failure. Eur J Heart Fail 2002; 4: 167-73.
- 11. Dai LJ, Friedman PA, Quamme GA. Acid-base changes
alter Mg2+ uptake in mouse distal convolutes
tubule cells. Am J Physiol 1997; 272: F759-F766.
- 12. Bos WJW, Postma DS, van Doormaal JJ.
Magnesiuric and calciuric effects of terbutaline in
man. Clin Sci 1988; 74: 595-7.
- 13. Cohen L, Laor A, Shnaider H, Kitzes R. Bone magnesium
in chronic obstructive pulmonary disease
with hypercapnia. Magnesium 1985; 4: 34-9.
- 14. Fiaccadori E, Del Canale S, Arduini U, et al.
Intracellular acid-base and electrolyte metabolism
in skeletal muscle of patients with chronic
obstructive lung disease and acute respiratory
failure. Clin Sci 1986; 71: 703-12.
- 15. Knochel JP. Pathophysiology and clinical
characteristics of severe hypophosphatemia. Arch
Intern Med 1977; 137: 203-20.
- 16. Haffner CA, Kendall MJ. Metabolic effects of b2-
agonists. J Clin Pharm Ther 1992; 17: 155-64.