Sıçanların Kalp Dokusunda Oksitosin’in Karbonik Anhidraz ve Asetilkolinesteraz Enzimleri Üzerine İnhibisyon Etkisinin Araştırılması

Çalışmamızda, sıçanlara enjekte edilen oksitosin, oksitosin reseptör antagonisti atosiban ve oksitosinatosiban

Anahtar Kelimeler:

enzim aktivitesi, karbonik anhidraz, oksitosin, rat

Investigation of Inhibition Effect of Oxytocin on Carbonic Anhydrase and Acetylcholinesterase Enzymes in the Heart Tissues of Rats

In our study, it was aimed to investigate the effects of oxytocin, oxytocin receptor antagonistatosiban and oxytocin-atosiban injected to rats on carbonic anhydrase (CA) and acetylcholinesterase (AChE)enzyme activities in the heart of rats. For this purpose, four different groups (n = 6) consisting of a total of 24rats, were formed. (Control group, oxytocin treated group, atosiban treated group, and oxytocin and atosibancombination treated group). The rats were necropsied after 60 minute intraperitoneal injection of the chemicals intothe rats. Cardiac tissue of rats was removed. The enzyme activity averages of the groups are statistically compared.According to this, while the activity of carbonic anhydrase enzyme in heart tissue of rats decreases in oxytocinand atosiban given groups, in the combination group with oxytocin and atosiban it was seen that the reductionwas relatively less according to the others. Acetylcholinesterase activity decreases in both groups of oxytocin andatosiban which given groups did not show any significant change in the group in which oxytocin and atosiban weregiven together.

Keywords:

enzyme activity, carbonic anhydrase, oxytocin, rat,

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