Ömer GÜNGÖR, Hatice ULUŞAN, Zafer YAZICIGİL

Fotodinamik Terapi İçin OktadodesiloksiSilicon(IV) Ftalosiyanin Bileşiğinin Sentezi ve Fotofizikokimyasal Özellikleri

Bu çalışmada, oktadodesiloksi silisyum(IV) ftalosiyanin türevi sentezlenmiş ve yapısı spektrofotometrik yöntemlerle aydınlatılmıştır. Sentezlenen ftalosiyanin bileşiği tetrahidrofuran, etil asetat, CH2Cl2, N,N dimetilformamid, dietil eter, CHCl3, etil alkol, ve asetonitril içinde iyi bir çözünürlük sergilemektedir. Silisyum ftalosiyanin bileşiğinin fotodinamik terapide fotoduyarlaştırıcı olarak kullanılabilirliğini araştırmak için fotofizikokimyasal özellikleri DMF içerisinde araştırılmıştır. Singlet oksijen, fotobozunma ve agregasyon özellikleri standart unsubstitüe silisyum ftalosiyanin ve çinko ftalosiyanin ile karşılaştırılmıştır. Singlet oksijen kuantum verimi’nin (ΦΔ) standart olarak kullanılan Si(IV)Pc’nin değerine çok yakın olduğu görülmüştür.

Anahtar Kelimeler:

Ftalosiyanin, silisyum, PDT, singlet oksijen

Synthesis and Photophysicochemical Properties of Octadodecyloxy Silicon(IV) Phthalocyanine for Photodynamic Therapy

Octadodecyloxysilicon(IV) phthalocyanine derivative was synthesized and its structure was determined by spectrophotometric methods. The synthesized phthalocyanine compound exhibits good solubility in tetrahydrofuran, ethyl acetate, CH2Cl2, N,Ndimethylformamide, diethyl ether, CHCl3, ethyl alcohol and acetonitrile. The photophysicochemical properties of the silicon phthalocyanine compound in photodynamic therapy were investigated in DMF. Singlet oxygen, photodegradation and aggregation properties were compared with standard unsaturated silicon phthalocyanine and zinc phthalocyanine. Singlet oxygen quantum yield (ΦΔ) was found to be very close to the value of Si (IV) Pc used as standard.

Keywords:

Phthalocyanine, silicon, PDT, singlet oxygen,

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