Hafif ve şiddetli preeklamptik gebelerdeki çözünebilir endotel protein C reseptor seviyesinin normotansif gebelerle üçüncü trimesterde karşılaştırılması

Amaç: Bu çalışmanın amacı, hafif ve şiddetli preeklampsi tanılı gebeler ile normotansif gebeler arasında sEPCR düzeylerini karşılaştırmaktır.Yöntem: Çalışmamıza, Atatürk Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniğine Şubat 2011 ile Eylül 2011 tarihleri arasında başvuran 18-40 yaş arası, 30 şiddetli preeklampsi, 30 hafif preeklampsi gebe dahil edildi. Kontrol grubu olarak ile 30 normotansif gebe seçildi. Alınan serumdaki sEPCR seviyesi ELISA ile ölçüldü.Bulgular: sEPCR seviyesi en yüksek şiddetli preeklemptik gebelerde (238±107 ng/ml), en düşük normotansif gebelerde (72±72 ng/ml) tespit edildi. Hafif preeklemptik gebelerde sEPCR seviyesi (134±85 ng/ml) şiddetli preeklemptik gebelerdekinden daha düşük saptandı (p

The comparison of the levels of soluble endothelial protein C receptor in mild and severe preeclamptic pregnants with normotensive group at third trimester

Objective: The aim of the study was to compare levels of soluble endothelial receptor (sEPCR) among women with severe preeclampsia, mild preeclampsia and normal pregnancy.Methods: The study was conducted at Ataturk University Faculty of Medicine, Department of Obstetrics and Gynecology between February 2011 and September 2011. Pregnant women aged between 18-40 years who had severe or mild preeclampsia were recruited consecutively for the study. Each group consisted of 30 patients. A total of 30 patients who had normal pregnancy were included in the study as a control group. A blood sample was taken from all patients and sEPCR test was performed.Results: Levels of sEPCR were highest in severe preeclamptic (238±107 ng/ml) and lowest in normal pregnant patients (72±72 ng/ml) (p<0.01). sEPCR level was lower in mild preeclampsia (134±85 ng/ml) than severe preeclampsia (p<0.01 for each comparision). There was a positive correlation between sEPCR with diastolic and systolic hypertension (r=0.263 and r=0.252 respectively).Conclusion: sEPCR is higher in preeclamptic pregnants and its level increases with the severity of the disease.

Kaynakça

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