ROMATOİD ARTRİTLİ HASTALARDA TÜMÖR NEKROZİS FAKTÖR–ALFA VE ERİTROPOETİN DÜZEYLERİ

Giriş: Romatoid artrit (RA) kronik ve inflamatuvar bir hastalıktır. Anemi, RA’de sık olarak gözlenmektedir. Bu çalışmada RA hastalarındaki anemide eritropoietin (Epo) ve tümör nekroz faktörü-alfa (TNFα) ilişkisi incelendi. Gereç ve Yöntem: Çalışmada 32 anemik, 31 anemik olmayan 63 RA’li hasta ile 20 sağlıklı kişiden oluşan kontrol grubu karşılaştırıldı. RA’li hastalar hemoglobin değerleri kadınlarda 12 g/dl, erkeklerde ise 13 g/dl sınır alınarak anemik ve anemik olmayanlar, anemik hastalar ise ferritin ve demir düzeyleri göz önüne alınarak demir eksikliği (n=15) ve kronik hastalık anemisi olanlar (n=17) şeklinde sınıflandırıldı. Serum TNFα, Epo, CRP, RF, ferritin, demir, demir bağlama kapasitesi, hemoglobin, hematokrit ve sedimentasyon düzeyleri belirlendi. Bulgular: Bu çalışmanın sonucunda tüm RA’ li hastaların Epo ve TNFα düzeyleri kontrol grubuna göre yüksek bulundu (p

LEVELS OF TUMOR NECROSIS FACTOR-ALPHA AND ERYTHROPOIETIN IN PATIENTS WITH RHEUMATOID ARTHRITIS

Introduction: Rheumatoid arthritis (RA) is a chronic and inflammatory disease. Anemia is common in RA. The aim of this study was to investigate the relationship between erythropoietin (Epo) and tumor necrosis factor-alpha (TNFα) in patients with RA. Material and Method: In this study, 32 anemic and 31 non-anemic of total 63 RA patients and 20 healthy controls were compared. Patients with RA were classified as anemic and non-anemic according to the hemoglobin values, with a limit of 12 g/dl in women and 13 g/dl in men. Anemic patients were classified as iron deficiency (n = 15) and chronic disease anemia (n = 17) according to ferritin and iron levels. Serum TNFα, Epo, CRP, RF, ferritin, iron, iron binding capacity, hemoglobin, hematocrit and sedimentation levels were determined. Results: As a result of this study, Epo and TNFα levels of all RA patients were higher than the control group (p

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