Introduction: Malignancy is rarely seen in pregnancy, and admission with superior vena cava syndrome (SVCS), which is an emergency case, is an unusual condition. We present a pregnant patient with VCSS. Case: A 32-year-old 27-week pregnant female patient, whose history revealed no known disease, presented with SVCS due to a mediastinal mass. The case managed by a multidisciplinary approach, was applied urgently biopsy and diagnosed as diffuse large B-cell lymphoma. Treatment was planned for the patient, and she was followed with no problems. A Caesarean section (C-section) was performed at the 35th week of the pregnancy. Conclusion: SVCS in pregnancy is an oncologic emergency disorder that is extremely rare encountered. The diagnosis of the patient as soon as possible is the key point of treatment. Oncologic treatment in this particular group of patients should be planned with both mother and fetus in mind.
Giriş: Gebelik sırasında malignite ile nadiren karşılaşılmaktadır, hastanın acil bir durum olan vena kava superior sendromu (VCSS) ile başvurması ise çok daha nadir bir durumdur. Çalışmamızda VCSS ile başvuran gebe olgu sunuldu. Olgu: Öncesinde bilinen hastalığı olmayan, 27. gebelik haftasında, 32 yaşında hasta VCSS’a neden olan mediastinal kitle ile başvurdu. Multidisipliner yaklaşım ile yönetilen olgu ivedilikle biyopsiye alındı ve diffüz büyük B hücreli lenfoma tanısı kondu. Tedavisi düzenlenen ve takibinde sorunu olmayan hasta 35. gebelik haftasında sectio sezeryan ile (S/C) doğurtuldu. Tartışma: Gebelikte VCSS son derece nadir karşılaşılan bir onkolojik acildir. Hastanın en kısa sürede tanı alması tedavide kilit noktayı oluşturmaktadır. Bu özel hasta grubunda onkolojik tedavi, hem anne hem de fetüs düşünülerek planlanmalıdır.
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Boere I, Lok C, Vandenbroucke T, Amant F. Cancer in pregnancy: safety and efficacy of systemic therapies. Curr Opin Oncol 2017; 29 (5): 328-34.
Cancer and pregnancy: poena magna, not anymore. Pentheroudakis G, Pavlidis N. Eur J Cancer 2006; 42 (2): 126–40.
Djakovic A, Ott G, Zollner U, Vordermark D, Dietl J. [Mediastinal large B-cell lymphoma with symptomatic superior vena cava syndrome in a patient with bichorial twin pregnancy in the 26th week of gestation: peri-and postpartal management -- a case report]. Zentralbl Gynakol 2005; 127 (4): 248-51.
Seligson MT, Surowiec SM. Superior Vena Cava Syndrome. [Updated 2017 Oct 6]. In: StatPearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 2018 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441981/
Cheng S. Superior vena cava syndrome: A contemporary review of a historic disease. Cardiol Rev 2009; 17 (1): 16-23.
Chan YK, Ng KP, Chiu CL, Rajan G, Tan KC, Lim YC. Anesthetic management of a parturient with superior vena cava obstruction for cesarean section. Anesthesiology 2001; 94 (1): 167-9.
Amant F, Han SN, Gziri MM, Vandenbroucke T, Verheecke M, Van Calsteren K. Management of cancer in pregnancy. Best Pract Res Clin Obstet Gynaecol 2015;29 (5): 741-53.
Pacifici GM, Nottoli R. Placental transfer of drugs administered to the mother. Clin Pharmacokinet 1995;28 (3): 235-69.
Lee EJ, Ahn KH, Hong SC, Lee EH, Park Y, Kim BS. Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy for diffuse large B-cell lymphoma in pregnancy may be associated with preterm birth. Obstet Gynecol Sci 2014; 57 (6): 526-9.