YÜZEYEL EEG’DE FARKLI İKTAL YAYILIM PATERNLERİ GÖSTEREN İLACA DİRENÇLİ TEMPORAL LOB EPİLEPSİLİ HASTALARDA POZİTRON EMİSYON TOMOGRAFİ

Amaç: Temporal lob epilepsili (TLE) hastaların cerrahi öncesi değerlendirilmesinde epileptojenik alanın belirlenmesi amacıyla yapılan flurodeoksiglukoz F 18’li positron emisyon tomografisi (FDG-PET) incelemesi önemli bilgiler sağlamaktadır. Bu çalışmada, yüzeyel iktal EEG kayıtlarında ‘switch-of lateralizasyon’ ve/veya ‘bilateral asenkroni’ izlenen TLE’li hastalarının interiktal FDG-PET incelemelerinde glukoz metabolizma verilerinin incelenmesi ve bu paternlerin izlenmediği TLE hastaları ile karşılaştırılması amaçlandı. Gereç ve Yöntem: Video-EEG monitörizasyon (VEM) incelemesinde en az bir nöbetinde ‘switch-of lateralizasyon’ ve ‘bilateral asenkroni’ saptanan 24 TLE’li hasta çalışmaya dahil edildi. Kontrol grubu olarak, bu iktal paternlerin izlenmediği, epilepsi cerrahisi geçirmiş ve 5 yıllık izlemi olan TLE hastaları belirlendi. Klinik, elektrofizyolojik ve görüntüleme bulguları değerlendirildi ve hasta grupları arasında istatistiksel olarak kıyaslandı. Bulgular: VEM’de ‘switch-of lateralizasyon’ ve/veya ‘bilateral asenkroni’ izlenen TLE’li hastalarda (%39), bu paternlerin izlenmediği gruba kıyasla (%0) FDG-PET incelemelerinde bilateral temporal hipometabolizma görülme oranı daha fazlaydı (p=0.040). Bu oran, bilateral interiktal epileptiform aktivite ve bilateral manyetik rezonans görüntülme anomalileri için de benzerdi. Opere olmuş ve VEM incelemelerinde ‘switch-of lateralizasyon’ ve/veya ‘bilateral asenkroni’ izlenen TLE’li hastalar içerisinde FDG-PET’de bilateral temporal hipometabolizma varlığı, cerrahi sonrası sonlanım açısından farklılık göstermemekteydi. Sonuç: Sonuçlarımız, cerrahi öncesi değerlendirmede VEM’de ‘switch-of lateralizasyon’ ve/veya ‘bilateral asenkroni’ izlenen TLE’li hastalarda FDG-PET bulgularının lateralizasyon değerlerinin dikkatli yorumlanması gerektiğini göstermiştir.

POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG

Objective: In presurgical evaluation, positron emission tomography with fluorodeoxyglucose-F18 (FDG-PET) is an important tool in identifying epileptogenic area. The aim of this study was to evaluate glucose metabolism in FDG-PET in patients with temporal lobe epilepsy (TLE) showing ‘switch-of lateralisation’ (SL) and ‘bilateral asynchrony’ (BA) in ictal scalp EEG and compare their results with patients with TLE and none of these patterns. Methods: Twenty-four patients with TLE showing SL and/or BA in at least one of their seizures in video-EEG monitoring and 38 patients with TLE and without these patterns who had epilepsy surgery and a follow-up at least 5-years were included. The clinical, electrophysiological and imaging features were evaluated and a statistical comparison was performed between the groups. Results: Bilateral hypometabolism was more frequent in patients with SL and/or BA (39%) than in patients without these patterns (0%, p=0.040) in parallel with bilateral interictal epileptiform discharges and bilateral abnormalities in MRI. The presence of unilateral or bilateral hypometabolism was not related to postsurgical outcome in patients with SL and/or BA. Conclusion: The possibility of low accuracy in the lateralisation of hypometabolism in FDG-PET might be interpreted cautiously in TLE with bilateral independent ictal activity like SL and BA.

Kaynakça

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Kaynak Göster

Bibtex @araştırma makalesi { iuitfd931629, journal = {Journal of Istanbul Faculty of Medicine}, issn = {}, eissn = {1305-6441}, address = {}, publisher = {İstanbul Üniversitesi}, year = {2021}, volume = {84}, pages = {175 - 180}, doi = {10.26650/IUITFD.2020.0053}, title = {POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG}, key = {cite}, author = {Şirin, Nermin Görkem and Marangozoğlu, Bedia and Yılmaz, Ebru and Gökyiğit, Ayşen and Baykan, Betül and Gürses, Candan and Bebek, Nerses} }
APA Şirin, N , Marangozoğlu, B , Yılmaz, E , Gökyiğit, A , Baykan, B , Gürses, C , Bebek, N . (2021). POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG . Journal of Istanbul Faculty of Medicine , 84 (2) , 175-180 . DOI: 10.26650/IUITFD.2020.0053
MLA Şirin, N , Marangozoğlu, B , Yılmaz, E , Gökyiğit, A , Baykan, B , Gürses, C , Bebek, N . "POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG" . Journal of Istanbul Faculty of Medicine 84 (2021 ): 175-180 <https://dergipark.org.tr/tr/pub/iuitfd/issue/62206/931629>
Chicago Şirin, N , Marangozoğlu, B , Yılmaz, E , Gökyiğit, A , Baykan, B , Gürses, C , Bebek, N . "POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG". Journal of Istanbul Faculty of Medicine 84 (2021 ): 175-180
RIS TY - JOUR T1 - POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG AU - Nermin Görkem Şirin , Bedia Marangozoğlu , Ebru Yılmaz , Ayşen Gökyiğit , Betül Baykan , Candan Gürses , Nerses Bebek Y1 - 2021 PY - 2021 N1 - doi: 10.26650/IUITFD.2020.0053 DO - 10.26650/IUITFD.2020.0053 T2 - Journal of Istanbul Faculty of Medicine JF - Journal JO - JOR SP - 175 EP - 180 VL - 84 IS - 2 SN - -1305-6441 M3 - doi: 10.26650/IUITFD.2020.0053 UR - https://doi.org/10.26650/IUITFD.2020.0053 Y2 - 2021 ER -
EndNote %0 İstanbul Tıp Fakültesi Dergisi POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG %A Nermin Görkem Şirin , Bedia Marangozoğlu , Ebru Yılmaz , Ayşen Gökyiğit , Betül Baykan , Candan Gürses , Nerses Bebek %T POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG %D 2021 %J Journal of Istanbul Faculty of Medicine %P -1305-6441 %V 84 %N 2 %R doi: 10.26650/IUITFD.2020.0053 %U 10.26650/IUITFD.2020.0053
ISNAD Şirin, Nermin Görkem , Marangozoğlu, Bedia , Yılmaz, Ebru , Gökyiğit, Ayşen , Baykan, Betül , Gürses, Candan , Bebek, Nerses . "POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG". Journal of Istanbul Faculty of Medicine 84 / 2 (Nisan 2021): 175-180 . https://doi.org/10.26650/IUITFD.2020.0053
AMA Şirin N , Marangozoğlu B , Yılmaz E , Gökyiğit A , Baykan B , Gürses C , Bebek N . POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG. İst Tıp Fak Derg. 2021; 84(2): 175-180.
Vancouver Şirin N , Marangozoğlu B , Yılmaz E , Gökyiğit A , Baykan B , Gürses C , Bebek N . POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG. Journal of Istanbul Faculty of Medicine. 2021; 84(2): 175-180.
IEEE N. Şirin , B. Marangozoğlu , E. Yılmaz , A. Gökyiğit , B. Baykan , C. Gürses ve N. Bebek , "POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG", Journal of Istanbul Faculty of Medicine, c. 84, sayı. 2, ss. 175-180, Nis. 2021, doi:10.26650/IUITFD.2020.0053

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