Leyla TÜRKER ŞENER, Serda KECEL GÜNDÜZ, Aziz ŞENER, Bilge BIÇAK, Yağmur KÖKCÜ, Ayşen E. ÖZEL, İşıl ALBENİZ

DOKSORUBİSİNİN MEME KANSERİ HÜCRELERİ İLE BİLGİSAYARLI TASARIMI

Amaç: Meme kanseri, meme hücrelerinde başlayan ve akciğer kanserinden sonra dünyada en yüksek insidansa sahip olan kanser türüdür. Doksorubisin, bazı lösemi ve Hodgkin lenfomasının yanı sıra mesane, meme, mide, akciğer, yumurtalık, tiroid, yumuşak doku sarkomu, multipl miyeloma ve diğer kanserlerin tedavisinde yaygın olarak kullanılır. Çalışmamızda; Doksorubisin’in Galektin 3’ün aktif bölgesinde yer alan, ASN-48, ARG-32, ASN-62 ve GLU-72 rezidüleri ile yaptığı bağlanma etkileşimlerini, konformasyonlarını ve doking skor enerjilerini belirlemek istedik.

Anahtar Kelimeler:

Doking, meme kanseri, Galektin-3, doksorubisin

COMPUTERISED DESIGNING OF DOXORUBICIN WITH BREAST CANCER CELLS

Objective: Breast cancer is the type of cancer that starts in breast cells and has the highest incidence in the world after lung cancer. Doxorubicin is widely used in the treatment of some leukemia and Hodgkin’s lymphoma, as well as in the treatment of bladder, breast, stomach, lung, ovary, thyroid, soft tissue sarcoma, multiple myeloma and other cancers. We want to determine the binding interaction of Doxorubicin in the active site of the Galectin-3 with ASN-48, ARG-32, ASN-62 and GLU-72 residues, conformation and docking score energies.

Keywords:

Docking, breast cancer, Galectin-3, Doxorubicin,

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