Akut Faz Reaksiyonlarına Patoloji Açısından Yaklaşım ve Türkiye’deki Genel Durum

Bu derleme, hayvanlarda hastalıkların teşhisinde duyarlı biyobelirteçler olarak kabul edilen akut faz proteinleri (AFP) ve akut faz reaksiyonunun (AFY) hem genel hem de patolojik açıdan önemini Türkiye'deki duruma özel bir vurgu yaparak değerlendirmektedir. Patolojik incelemeler, dünya çapında veteriner hekimlik alanında AFP’leri ve AFY'yi araştıran çalışmalarda yaygın olarak kullanılmaktadır. Buna karşılık Türkiye'de, hem çalışma sayısı hem de patolojinin katılımı sınırlıdır. Bu nedenle konunun önemini vurgulamak ve klinisyenlerin farkındalığını arttırmak için dünyada ve Türkiye'de yapılan çalışmaların nitel ve nicel bir analizini yaptık. Bu derleme, Türkiye'de konuyla ilgili yapılan ilk kapsamlı çalışmadır ve yapılan çalışmaların dağılımının bölgesel bir haritası ile desteklenmektedir.

Anahtar Kelimeler:

Akut faz protein, akut faz yanıt, C-reaktif protein, haptoglobin, sekonder amiloidozis, serum amiloid A

Approach to Acute Phase Reactions in the Aspects of Pathology and General Situation in Turkey

This review evaluates the importance of acute phase proteins (APP) and acute phase reaction (APR), which are accepted as sensitive biomarkers in diagnosing of animal diseases, both in general and pathological terms, with a particular emphasis on the situation in Turkey. Pathological examinations have been extensively used in studies investigating the APP and APR in veterinary medicine globally. In contrast, the number of studies and pathology involvement is limited in Turkey. For this reason, we conducted a qualitative and quantitative analysis of the studies in the world and in Turkey to emphasize the importance of the subject and increase awareness among the clinicians. The review is the first comprehensive report on the subject in Turkey and is supported by a regional map of the distribution of performed studies.

Keywords:

Acute phase protein, acute phase reaction, C-reactive protein, haptoglobin, secondary amyloidosis, serum amyloid-A,

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