Uterine lipoleiomyoma: Review of literature and two case reports

Lipoleiomyom, matür adipöz doku ve düz kas komponenti içeren, nadir görülen mezenkimal bir neoplazmdır. Tüm uterin lei omyomlar içerisinde görülme sıklığı %0,03-0,2 arasında değişmektedir. Bu çalışmada iki lipoleiomyom olgusu klinik, histopatolojik ve etiyopatogeneze yönelik bilgiler eşliğinde sunulmuş tur. İlk olgu 59 yaşında, postmenopozal kanama yakınması ile başvuran kadın hasta olup, myoma uteri klinik tanısı ile histerektomi operasyonu uygulanmıştır. İkinci olgu, postkoital kanama yakınması ile başvuran 45 yaşında kadın hastadır. Uterin serviks yerleşimli polipoid lezyon eksize edilmiştir. Her iki olguya ait operasyon materyallerinin histopatolojik incelemesinde değişen oranlarda adipöz doku ve düz kas komponenti içeren, ilk olguda intramural, ikinci olguda submukozal yerleşimli lipoleiomyom saptanmıştır. Leiomyomlarda düz kas hücreleri yanı sıra diğer heterolog elemanların görülmesi nadirdir. Adipöz dokunun %10’dan fazla olması lipoleiomyom tanısını akla getirmelidir.

Uterin lipoleiomyom: Literatürün gözden geçirilmesi ve iki olgu sunumu

Lipoleiomyoma is uncommon mesenchymal neoplasm which contains mature adipose tissue and smooth muscle components. Its prevalence among all uterine leiomyomas varies between 0,03-0,2% . In the current study, we present two lipoleiomyoma cases alongside clinical and histopathological data as well as information on etiopathogenesis. The first case was a 59-year-old female patient presented with postmenopausal hemorrhage and she was subjected to hysterectomy upon clinical diagnosis of myoma uteri. Second case was a 45-year-old woman who presented with postcoital hemorrhage. Polypoid lesion which had a uterine cervix localization was excised. Histopathological examination of the operation materials belonging to these two cases, revealed intramural (first case) and submucosal (second case) lipoleiomyoma, both of which had a varying degree of adipose tissue and smooth muscle components. In leiomyoma cases, detection of other heterologous components alongside smooth muscle cells, is an uncommon event. Presence of an adipose tissue higher than 10%, should indicate lipoleiomyoma.

Kaynakça

1. Kondi-Pafiti A,Grapsa D,Kairi-Vassilatou E, Kontogianni - Katsarou K, Koliopoulos C, Botsis D. Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature. Eur J Gynaecol Oncol 2006; 27:73-7.

2. Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases. Am J Surg Pathol 1994;1535-58.

3. Aung T, Goto M, Nomoto M, et al.Uterine lipoleiomyoma: a histopathological review of 17 cases. Pathol Int 2004; 54:751-8.

4. Wang X, Kumar D, Seidman JD et al. Uterine lipoleiomyomas: a clinicopathologic study of 50 cases. Int J Gynecol Pathol. 2006;25:239-42.

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Kaynak Göster

  • ISSN: 1300-4751
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1995

7.5b 3.1b

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