Recurrent Cystic Hygroma with Normal Karyotype in Two Consecutive Pregnancies

We herein describe a woman with two consecutive pregnancies affected by fetal nuchal cystic hygroma(CH) with a normal karyotype.A 33-year-old woman (gravidity 2, parity 1) was referred to us because of fetal hydrops. No consanguinity or Rh isoimmunization was involved in her current or previous pregnancy. First-trimester ultrasonography revealed nuchal CH, and chorion villus sampling was performed to exclude aneuploidy.In the first pregnancy, the CH had regressed and aortic coarctation was detected by second-trimesterfetal echocardiography. In the current pregnancy, the CH had progressed and was complicated by thedevelopment of nonimmune hydrops. Termination of the pregnancy was performed at 21 weeks' gestation. Recurrence of fetal CH in subsequent pregnancies is extremely rare. CH with a normal karyotype canbe inherited as an autosomal recessive trait. This report describes a woman with recurrent CH with normal karyotypes and different prognoses.

Kaynakça

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Heinonen S, Ryynänen M, Kirkinen P. Etiology and out- come of second trimester non-immunologic fetal hydrops. Acta Obstet Gynecol Scand 2000;79(1):15-8.

Hutchison AA, Drew JH, Yu VY, Williams ML, Fortune DW, Beischer NA. Nonimmunologic hydrops fetalis: a re- view of 61 cases. Obstet Gynecol 1982;59(3):347-52.

Machin GA. Hydrops revisited: literature review of 1.414 cases published in the 1980s. Am J Med Genet 1989;34 (3):366-90.

Baxi L, Brown S, Desai K, Thaker H. Recurrent cystic hy- groma with hydrops. Fetal Diagn Ther 2009;25(1):127-9.

Teague KE, Eggleston MK, Muffley PE, Gherman RB. Recurrent fetal cystic hygroma with normal chromo- somes: case report and review of the literature. J Matern Fetal Med 2000 Nov-Dec;9(6):366-9.

Tanriverdi HA, Ertan AK, Hendrik HJ, Remberger K, Schmidt W. Outcome of cystic hygroma in fetuses with normal karyotypes depends on associated findings. Eur J Obstet Gynecol Reprod Biol 2005;118(1):40-6.

Desilets V, Audibert F. Investigation and management of non-immune fetal hydrops. J Obstet Gynaecol Can 2013;35(10):923-38.

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Beke A, Joó JG, Csaba A, Lázár L, Bán Z, Papp C, et al. Incidence of chromosomal abnormalities in the presence of fetal subcutaneous oedema, such as nuchal oedema, cystic hygroma and non-immune hydrops. Fetal Diagn Ther 2009;25(1):83-92.

Kaynak Göster

  • ISSN: 1300-4751
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1995

17.9b 8.9b

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