Effect of basal testosterone and dehydroepiandrosterone sulphate levels on in vitro fertilization outcome in normoresponders

AMAÇ: Bu çalışmanın amacı normoresponder hastalarda ba- zal androjen düzeylerinin IVF sonuçlarına etkisini değerlendir- mektir. GEREÇ VE YÖNTEM: İlk IVF/ET denemesi için kabul edilen 60 normoresponder hastanın siklusun 2-4. günlerinde bazal serum FSH, LH, E2, Total-Testosteron (total-T), Dehidroepi- androsteron sülfat (DHEAS) düzeyleri ve antral follikül sayıları (AFS) değerlendirildi. BULGULAR: Gebe kalan ve kalamayan hastalar karşılaştırıldı- ğında AFS, hormon ve kontrollü ovaryan hiperstimülasyon (KOH) parametreleri (kullanılan total gonadotropin miktarı (1995,7±851,1 vs 2296,4±845,3 IU), 14 mm üzerinde folikül sa- yısı (9,3±3,1 vs 7,3±3,9), elde edilen oosit sayısı (12,4±5,1 vs 8,7±6,1) ve iyi kalitede embriyo sayıları (7,4±3,7 vs 4,4±3,6) arasında istatistiksel olarak anlamlı fark saptanmadı (p>0,005). Testosteronun ve DHEAS ile KOH parametreleri arasında ista- tistiksel olarak anlamlı korelasyon saptanmadı (p>0,05). SONUÇ: Normoresponder hasta grubunda bazal testosteron ve DHEAS düzeyleri ile İVF stimülasyon parametreleri arasın- da korelasyon yoktur.

Normoresponder hastalarda bazal testosteron ve dehidroepiandrosteron sülfat düzeylerinin in vitro fertilizasyon sonuçlarına etkisi

OBJECTIVE: The purpose of the present study is to evaluate the predictive value of basal total testos- terone (total-T) and dehydroepiandrosterone sulphate (DHEAS) levels in normoresponder patients un- dergoing IVF-ET. STUDY DESIGN: A total of 60 normoresponder infertile women, scheduled to undergo their first IVF/ET cycle were enrolled in this study. Day 2-4 basal concentrations of FSH, LH, E2, total testosterone, DHEAS and antral follicle count (AFC) were determined in preceding cycle. RESULTS: No significant difference was found between pregnant and non-pregnant groups regarding the AFC, hormone and controlled ovarian hyperstimulation (COH) parameters (total dose of go- nadotrophins (1995.7±851.1 vs 2296.4±845.3 IU), >14 mm follicles (9.3±3.1 vs 7.3±3.9), retrieved oocytes (12.4±5.1 vs 8.7±6.1) or number of good quality embryos (7.4±3.7 vs 4,4±3.6) (p>0.05). Testosterone and DHEAS was not correlated with COH parameters (p>0.05). CONCLUSION: There is no correlation between testosterone and DHEAS levels and COH parameters in normoresponder IVF patients.

Kaynakça

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