Doğal Bitki Antibiyotiği: Resveratrol

Fitoaleksinler, bitkilerde mikrobiyal enfeksiyon, yaralanma ve ultraviyole ışınlara tepki olarak sentezlenen düşük molekül ağırlığındaki ikincil metabolik maddelerdir. Resveratrol (trans-3, 4', 5-trihydroxystilbene), 72 adet bitki türünde bulunan 31 cins ve 12 familyada dağılım gösteren bir fitoaleksindir. Üzüm ve kırmızı şarap gibi üzüm ürünleri ile yer fıstığı, yer fıstığı yağı, şam fıstığı, siyah çikolata ve kakao likörü gibi diğer bitkisel ürünlerde doğal olarak bulunan antioksidandır. Resveratrol'ün pıhtı önleyici, çeşitli fungus ile virüs gelişimini durdurucu ve kansere karşı engelleyici etkisi vardır. Resveratrol içeren ürünlerin birçoğu yurdumuzda yetiştirilmektedir. Bu nedenle, bu ürünlerden özütlenerek ilaç formuna getirilmesi, ülkemizdeki ilaç firmaları için yeni fırsatlar yaratabilecektir.

Anahtar Kelimeler:

Trans-resveratrol, fitoaleksin, ikincil metabolit maddeler, UV ışık

Natural Plant Antibiotics: Resveratrol (Turkish with English Abstract)

Phytoalexins are low molecular weight secondary metabolites made by plants as a defense response to microbial infections, wounding and UV radiation. Resveratrol (trans-3, 4', 5-trihydroxystilbene), is a phytoalexin found in at least 72 species of plants distributed among 31 genera and 12 families. It is a naturally occurring antioxidant found in grapes, grape products such as red wine and some other botanical sources like peanuts and peanut butter, pistachio, dark chocolate and cocoa liquor. Resveratrol exhibits a wide range of biological effects, including anti-platelet, anti-cancer, anti-fungal and anti-viral properties. Most of the agricultural products that contain resveratrol are produced in Turkey. Thus, it will be a new challenge for the pharmaceutical industry when it is extracted from these products and turned into drug form.

Keywords:

trans-resveratrol, phytoalexin, secondary metabolites, UV radiation ,

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