Üst gastrointestinal kanama ve Helikobakter pilori arasındaki bağlantı

Amaç: Üst gastrointestinal kanamalı çocuklarda Helikobakter pilori pozitifliğinin araştırılması. Yöntem: Çalışmaya alınan üst gastrointestinal kanamalı 19 çocuğa endoskopi uygulandı, histolojik, serolojik yöntemlerle ve üreaz testi ile Helikobakter pilorinin varlığı araştırıldı. Bulgular: 19 olgudan 10'unda (% 53) Helikobakter pilori bulundu. Endoskopik olarak duodenal ülser saptanan olguların % 66.0'smda Helikobakter pilori pozitif idi. Sonuç: Üst gastrointestinal kanama ile gelen olguların % 53'ünde Helikobakter pilori bulunması, bu hastalarda Helikobakter pilori pozitifliğinin araştırılması ve bulunduğunda tedavi edilmesi gerektiğini düşündürmektedir.

The relation between upper gastrointestinal heamorrhagia and Helicobacter pylori

Objective: The aim of the study was to investigate the positivity of Helicobacter pylori on the patients with upper gastrointestinal haemorrhage. Methods: Nineteen children with upper gastrointestinal haemorrhage underwent endoscopie investigations of the upper gastrointestinal tract. Helicobacter pylori positivity was investigated by histological, serological methods, and urease test. Results: In 10 of 19 (53%) patients Helicobacter pylori was found to be positive. Helicobacter pylori positivity was identified in 66.0% of duodenal ulcer patients diagnosed with endoscopy. Conclusion: Since Helicobacter pylori was found to be positive in 53% of the patients with upper gastrointestinal haemorrhagia it would be logical to seek and if present to treat Helicobacter pylori in these patients.

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  • Mervin S, Fredric D. Textbook of pediatric gastroenterology. New-York; Haven Press; 1988. Olson AD, Hillemeirer AC. Gastrointestinal hemorrhage. In: Wyllie R, Hyams JS, editors. Pediatric gastrointestinal disease. Philadelphia: WB Saunders;1993. p. 251-70. Drumm B Perez-Perez GI, Blaser BJ, et al. Intrafamilial clustering of Helicobacter pylori infection. N Engl J Med 1990; 322:359-63. Drumm B, Sherman P, Cutz E, Karmali M. Association of campylobacter pylori on the gastric mucosa with antral gastritis in children. N Engl J Med 1987; 316:1557-61. Desforges JF. Helicobacter pylori and peptic ulcer disease. N Engl J Med 1991; 324:1043-9. Schubert TT, Bolognu SD, Nevey Y, Schubert AB, Mascha ES, Ma CK. Ulcer risk factors: Interactions between helicobacter pylori infection, nonsteroidal use, and age. Am J Med 1993;94:13-8. Adamek RJ, Freitag M, Opferkuch W, Ruhl GH, Wegener M. Intravenous Omeprazole /Amoxicillin and Omeprazole pretreatment in Helicobacter pylori-positive acute peptide ulcer bleeding: A pilot study. Scand J Gastroenterol Hepatol 1994;29:880-3. Henriksson AE, Edman AC, Held M, Wadstrom T. Helicobacter pylori and acute bleeding peptic ulcer. Eur J Gastroenterol Hepatol 1995;7:769-71. Tytgat GN. Peptic ulcer and Helicobacter pylori: Eradication and relapse. Scand J Gastroenterol 1995;210(Suppl):70-2. Rauws EJ, Tvtgat GN. Helicobacter pylori in duodenal and gastric ulcer disease. Baillieres Clin Gastroenterol 1995;9:529-47. Chamg MH, Wang TH, Hsu JY. Endoscopic examination of upper gastrointestinal tract in infancy. Gastrointest Endos 1983;29:15-7. Charles B, Hangrove MD, Martin H. Upper gastrointestinal endoscopy in infants: Diagnostic usefulness and safety. Pediatrics 1984;74:828-31. Çorbacıoğlu D, Yavuz C, Vitrinel A. Çocuklarda üst gastrointestinal kanamalarda endoskopinin yeri. Haydarpaşa Numune Derg 1992;32:138-40. Deckelbaum RJ, Roy CC, Lussier-Lazaroff L. Peptic ulcer disease: A clinic study in 73 children. Can Med Assoc J 1974;111:225-8. Habbick BF, Melrose AC, Grant JC. Duodenal ulcer in childhood. Arch Dis Child 1968;3:23-7. Nord KS, Rossi TM, Lebenthal E. Peptic ulcer in children. The predominance of gastric ulcers. Am J Gastroenterol 1981; 75:153-7. Tudor RB. Letter to the editor. Lancet 1974;2:219. Prieto G, Isabel P, Lurrauri J. Helicobacter pylori infection in children: Clinical, endoscopic and histologic correlations. J Pediatr Gastroent Nutr 1992;14:420-5. De Giacamo L, Fiaco R. Helicobacter pylori infection and chronic gastritis: Clinical, serological, and histologic correlations in children treated with amoxicillin and colloidal bisbuth subcitrate. J Pediatr Gastroenterol Nutr 1988;11:310-6. Mitchel HM, Bohane JD. Antibody to Campylobacter pylori in families of index children with gastrointestinal illness due to Campylobacter pylori. Lancet 1987;2:681-2. Malaty HM. Graham DY, Klein PD, Evans DG. Transmission of Helicobacter pylori infection: Studies in families of healthy individuals. Scand J Gastroenterol 1991;26:927-32. Kilbridge M, Dahms B. Campylobacter pylori-associated gastritis and peptic ulcer disease in children. ADJC 1988;142:1149-52. Kenneth C, Mervin E, Ament ME. Gastrointestinal bleeding in children and adolescents. Pediatrics 1979;63:408-13. Tümay G, Kutlu T, Çullu F. Çocuklarda Helicobacter tanı ve tedavisi. 16. Pediatrik Gastroenteroloji ve Hepatoloji Kongresi. İstanbul; 1994.