Radyasyon enteritinde lifli besinlerin koruyucu etkisi

Amaç: Bu çalışmanın amacı radyasyon enteriti oluşturulmuş ratlarda suda tamamen eriyen ve suda hiç erimeyen lifli besinlerin bakteriyel translokasyona etkisini ve barsaklarda oluşan histopatololojik değişiklikleri araştırmaktı. Yöntem: Her bir grupta 15 adet sıçan olmak üzere sıçanlar üç gruba ayrıldıktan sonra 1100 cGy tüm abdominal radyoterapi ile radyasyon enteriti oluşturuldu. Grup 1 sadece standart besin ile Grup-2 suda erimeyen lifli besin (Nutrodrip-Fiber) ile Grup 3 ise suda eriyen lifli besin (Sando-Source) ile bir haftalık beslenme programına alındı. Bulgular: Grup 2'de ince barsak villus boyu ve ince barsak duvar kalınlığı anlamlı oranda yüksek bulundu. Sonuç: Radyoterapiye bağlı barsaklarda oluşan hasarların önlenmesinde suda erimeyen lifli besinlerin kullanımının yararlı olabileceği kanaatine varıldı.

Anahtar Kelimeler:

Bakteriyel translokasyon, Diyet, Diyet lifi, Enterit, Radyasyon, Sıçanlar

Protective effects of fiber enriched diet in radiation enteritis

Objective: The aim of this study was to determine the effects of both the water soluble and water insoluble fiber enriched diet on bacterial translocation and investigate the histopathological changes in the intestines, in a rat model of radiation enteritis. Methods: Following irradiation, with a single dose of 1100 cGy into abdomen 45 rats were randomised into three groups. The first group intook Standard fıber-free diet, the second group consumed water insoluble fiber enriched diet and the third group intook water soluble fiber enriched diet for seven days. Results: in group 2 height of intestinal villi and the wall thickness of small intestines were higher than the other groups. Conclusion: The water insoluble fiber enriched diet may prevent the effects of radiation on the intestines.

Keywords:

Bacterial Translocation, Diet, Dietary Fiber, Enteritis, Radiation, Rats,

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Bu çalışma Eylül 2001’de Almanya -Munich’de yapılan ESPEN - Nutrition kongresinde bildiri olarak sunulmuştur.

ISSN: 2602-3741
Yayın Aralığı: Yılda 6 Sayı
Başlangıç: 1997
Yayıncı: SELÇUK ÜNİVERSİTESİ > TIP FAKÜLTESİ

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