Yavuz T. GEDERET, BAHADIR ÖZTÜRK, Emrah KARAGÖZOĞLU, Mehmet GÖK, A. Muhtar TİFTİK

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Malign-nonmalign plevral efüzyon ayırıcı tanısında IGF ve IGFBP’lerin rolü

Amaç: IGF’ler, Büyüme Hormonunun (GH) periferik etkilerine aracılık eden polipeptidlerdir. IGF’lerin, hücre büyümesi ve proliferasyonunda önemli etkileri vardır. Son yıllarda yapılan çalışmalarda IGF’lerin malign proliferasyonda da rolleri olduğu ortaya çıkmıştır. Çalışmamızda IGF ve bağlayıcı proteinlerin akciğer kanseri ve nonspesifik plöritiste seviyeleri ve malignite ile ilişkisi araştırıldı. Yöntem: Bu çalışmaya değişik nedenli plevral efüzyonu bulunan toplam 40 hasta alındı. Hastalar, konulan tanılara göre akciğer kanseri ve nonspesifik plörezi şeklinde iki gruba ayrıldı. Her bir grupta 20 hasta vardı. Bu hastalardan alınan serum ve plevral sıvı örneklerinde IGF I-II, IGFBP I-II analizleri yapıldı. Bulgular: Serumda IGFBP-I ve IGFBP-II, malign grupta anlamlı olmasa da yüksek iken, plevral sıvıda IGFBP-I düşük, IGFBP-II ise yüksek bulundu. Serum IGF-II ve plevral sıvı IGF-II seviyesi malign grupta anlamlı şekilde yüksek bulundu. Plevral sıvı IGF-I seviyesi malign grupta anlamlı şekilde yüksek bulundu. Sonuç: IGF’lerin etkilerine aracılık eden bağlayıcı proteinlerin malignitede yükseldiğini, plevral sıvı değerleri açısından da farklılık gösterdiğini tespit ettik. Malignitede özellikle etkili olan IGF-II ise plevral sıvıda, serumdan daha belirgin olarak yükselmektedir.
Anahtar Kelimeler:

İnsülin-benzeri büyüme faktörü bağlayıcı proteinler, Akciğer neoplazmları, Plevral efüzyon, Plörezi, Somatomedinler

The role of IGF and IGFBP in distinguishing malign-nonmalign pleural effusion

Objective: IGF’s are polypeptides those mediates peripheral effects of GH. IGF’s have important roles in cell proliferation and growth. Also recent studies show IGF’s have important roles in malign proliferation. In this study it was aimed to investigate IGF’s and binding protein’s levels in lung carcinoma and nonspecific pleuritis. Methods: Patients which have pleural effusion, caused by different effects, were taken to this study. Patients were divided into two groups by their diagnosis; 20 were lung cancer, 20 were nonspecific pleuritis. Pleural fluids and seras were taken from patients to determine IGF-I-II and IGFBP I-II levels. Results: In malignancy patients, sera’s IGFBP-I and II levels were increased although it was not significant and pleural fluid’s IGFBP-I levels were significantly decreased and IGFBP-II levels were significantly increased. Sera’s and pleural fluid’s IGF-II levels significantly increased than the other group. The malignancy patient’s pleural fluid’s IGF-I levels were found significantly increased. Conclusion: Binding proteins that mediate the effects of IGF were increased in patients with malignancy. Binding proteins showed differences in pleural fluid of the patients. IGF-II that has important effects on malignancy showed significant increase in pleural fluid than sera.
Keywords:

Insulin-Like Growth Factor Binding Proteins, Lung Neoplasms, Pleural Effusion, Pleurisy, Somatomedins,

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Genel Tıp Dergisi-Cover
  • ISSN: 2602-3741
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1997
  • Yayıncı: SELÇUK ÜNİVERSİTESİ > TIP FAKÜLTESİ
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