Mustafa AYDIN, RAFET KOCA, Ali ÖZEREN, Cevdet ALTINYAZAR

Kronik idiyopatik ürtikerli hastalarda kardiyak otonomik aktivitenin kalp hız değişkenliği ile değerlendirilmesi

Amaç: Kronik idiyopatik ürtikerli (KİÜ) hastalarda kalp hız değişkenliği kullanılarak kardiyak otonomik aktivitenin araştırılması amaçlandı. Metot: Çalışmaya 24 KİÜ’li hasta (18 kadın ve 6 erkek, yaş ortalaması 29±12 yıl) ve 18 sağlıklı birey (15 kadın ve 3 erkek, yaş ortalaması 28±10 yıl) dahil edildi. Her iki gruba 24 saat süreyle holter elektrokardiyografi uygulanarak zaman ve frekans bağımlı kalp hız değişkenliği parametreleri hesaplandı. Frekans bağımlı analiz parametrelerinden çok düşük frekans komponenti (VLF), düşük frekans komponenti (LF), yüksek frekans komponenti (HF) ve LF/HF, zaman bağımlı değişkenlerden 24 saat içindeki tüm normal sinus R-R intervallerinin standart deviasyonu (SDNN), 24 saatlik kayıt boyunca her 5 dakikalık segmentlerde normal sinus R-R intervallerinin ortalamasının standart deviasyonu (SDANN), normal sinus RR intervallerinde ardışık değişimlerin ortalama karekökü (RMS-SD) kullanıldı. Bulgular: KİÜ grubunda SDANN kontrole göre anlamlı düzeyde artmış olarak izlendi. Buna karşın HF, LF ve LF/HF, ve SDNN değerlerinde anlamlı değişim izlenmedi. Sonuç: Elde edilen sonuçlar KİÜ’li hastalarda dengelenmiş sempatik/parasempatik aktiviteye işaret etmektedir.

Anahtar Kelimeler:

Kalp hızı, Kalp damar sistemi, Ürtiker, Elektrokardiyografi, ayakta

Assessment of cardiac autonomic activity in patients with chronic idiopathic urticaria by heart rate variability

Objective: The aim of the present study was to evaluate cardiac autonomic nervous system functions in chronic idiopathic urticaria (CIU) by using 24- hour Holter electrocardiogram. Method: The study group consisted of 24 patients with CIU (18 female and 6 male, 29±12 years) and the control group consisted 18 healthy participitants (15 female, and 3 male, 28±10 years). In these two groups, we assessed cardiac autonomic regulation by power spectral analysis and time dependent analysis of heart rate variability (HRV) using 24-hour Holter electrocardiogram. Frequency components of the power spectra consist of high frequency component (HF), low frequency component (LF), very low frequency component (VLF), and the ratio of low frequency component and high frequency component (LF/HF). Time dependent HRV consists the standard deviation of all normal sinus RR intervals over 24 h (SDNN), standard deviation of all averaged normal sinus intervals for each 5-min segment in the 24-h recording (SDANN) and the root mean square of successive differences between normal sinus RR intervals (RMS-SD). Results: SDANN increased significantly in the CIU group compared to controls. Contrary to this HF, LF, LF/HF and SDNN values were similar to controls. Conclusion: In the CIU group, power spectral analysis and time dependent variable reflecting balanced cardiac autonomic activity.

Keywords:

Heart Rate, Cardiovascular System, Urticaria, Electrocardiography, Ambulatory,

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