Ahmet SALBACAK, İ. İlknur UYSAL, Mustafa BÜYÜKMUMCU, A. Kağan KARABULUT

İnsan fötuslarında kalp gelişiminin ve kalbin morfolojik yapısının diseksiyon yöntemi ile araştırılması

Amaç: Bu çalışmada 2. ve 3. trimestr insan fötuslarında kalbin normal gelişim modelinin belirlenmesi, sağ ve sol kalbe ait duvar kalınlıklarındaki değişikliklerin tespit edilmesi, interventriküler ve interatrial septum bölümlerinin kalınlık ve uzunluk ölçümlerinin yapılarak elde edilen verilerin gestasyonel yaşla ve cinsiyetle korelasyonunun araştırılması planlandı. Yöntem: Anatomi Anabilim Dalı fetus kolleksiyonundan alınan, dış görünümünde anomali gözlenmeyen, spontan abort 70 adet fötus kalbi kullanılarak 12 adet parametrik ölçüm alındı. Kalplerden alınan ölçüm verileri ile gestasyonel yaş arasındaki ilişki korelasyon analiz yöntemi ile istatistiksel olarak değerlendirildi. Ayrıca verilerin tamamının her iki cins arasında, ve buna ilaveten duvar kalınlıklarının sağ-sol karşılaştırılması student-t testi ile yapıldı. Bulgular: Kalp duvar kalınlıkları ile gestasyonel yaş arasında anlamlılık derecesi değişmekle beraber tüm parametrelerde istatistiksel olarak anlamlı linear regresyon saptandı. Ortalama değerlerin sağ tarafta tüm parametrelerde daha büyük olduğu gözlendi. Değerlendirilen parametrelerin 3’ünde cinsiyete göre önemli fark saptandı. Sonuç: Bu çalışma ile 2. ve 3. trimestr’da insan fötus kalp duvarlarının normal gelişimine ait veriler elde edilmiş olup, bu verilerin klinik uygulamalarda temel oluşturacağı kanaatindeyiz.

Anahtar Kelimeler:

Kalp, Düşük, kendiliğinden, Anatomi, Gebelik yaşı, Fetal gelişim, Diseksiyon, Fetüs

An investigation of the development of human fetal heart and its morphological structure by dissection

Objective: In this study, we aimed to investigate the normal developmental pattern of the human fetal heart in second and third trimester, the differentiation of the right and left heart wall thickness, and to assess the length and width of the interventricular and interatrial septum, and to evaluate the correlation of the values with the gestational age and sex. Method: 70 spontaneously aborted human fetuses with no external malformations obtained from the fetus collection of Anatomy Department were studied and 12 parameters from each were assessed. The relationship of these parameters with the gestational age was evaluated by correlation analyses using statistical methods. In addition, the values were compared between the sexes and sides using student’s t-test. Results: There was statistically significant linear relationship between the heart wall thickness and gestational age. Amongst the evaluated parameters three of them were significantly different between according to gender. Conclusion: This study presents the normal values of the developing fetal heart in the 2nd and the 3rd trimester, and we believe that these values may provide a useful background information for the clinical approaches.

Keywords:

Heart, Abortion, Spontaneous, Anatomy, Gestational Age, Fetal Development, Dissection, Fetus,

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