Burak TAN, ERCAN BABUR, Hikmet FIRAT, CEM SÜER, NURCAN DURSUN

Hipertiroidili sıçanlarda uzamsal öğrenme performansına cinsiyetin etkisi

Amaç: Gelişimsel dönemdeki hipotiroidi ve hipertiroidi gibi tiroid hormon seviyesi bozukluklarında, beyinde yapısal ve fonksiyonel değişikliklerin olduğu deneysel çalışmalarda gösterilmiştir. Bu değişikliklerin, hipokampüsün önemli rol oynadığı öğrenme ve bellek gibi bilişsel süreçlerde bozulmalara ve nörolojik bozukluklara neden olduğu bilinmektedir. Bu amaçla hipertiroidili erkek ve dişi sıçanlar arasında uzamsal öğrenme performansının araştırılması amaçlanmıştır. Gereç ve Yöntem: Hipertiroidi oluşturmak için erkek ve dişi sıçanlara 21 gün süreyle 0,2 mg/kg dozda L-Tiroksin İp olarak uygulanmıştır. Öğrenme ve bellek performansını değerlendirmek için Morris su tankı testi (MST) kullanılmıştır. Bulgular: Tekrarlayan ölçümlerle ANOVA testi yapıldığında cinsiyet faktörü platforma olan ortalama uzaklığı anlamlı (p

Objective: In thyroid hormone level disorders such as hypothyroidism and hyperthyroidism in developmental period, experimental studies have shown that structural and functional changes in the brain. These changes are known to cause neurological disorders and impairments in cognitive processes, such as learning and memory, in which the hippocampus plays an important role. For this purpose, it is aimed to investigate spatial learning performance between hyperthyroidized male and female rats. Materials and Methods: Male and female rats were administered with L-thyroxine intraperitoneally at a dose of 0.2 mg/kg for 21 days to induce hyperthyroidism. Morris water maze (MWM) was used to assess learning and memory performance. Results: When repeated ANOVA tests were performed, the gender factor significantly affected the mean distance to the platform (p

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