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Endoskopi yapılan hastalarda eroziv reflü hastalığının sıklığı, endoskopik, klinik ve histopatolojik özellikleri ve Helicobacter pylori ile ilişkisi

Amaç: Gastroözofageal reflü hastalığı, noneroziv reflü hastalığı (NERH), eroziv reflü hastalığı (ERH) ve Barrett özofagus olmak üzere 3 grup olarak tanımlanır. Bu çalışmanın amacı, endoskopi yapılan hastalarda ERH'nin sıklığı, endoskopik, klinik özellikleri ve Helicobacter pylori (H. pylori) infeksiyonu ile ilişkisini değerlendirmektir. Gereç ve yöntem: Üst gastrointestinal sistem endoskopisi yapılan ve histopatolojik değerlendirme ve H. pylori için antrum-korpusdan biyopsi alınan 1840 hasta geriye dönük olarak değerlendirildi. ERH tanısı Los Angeles sınıflandırmasına göre yapıldı. Bulgular: Endoskopik olarak, 1840 hastanın 531'inde (%28.9) ERH tespit edildi. ERH olan hastaların ortalama yaşı 49.4±18.8 yıldı. Hastaların 251'i (%47.2) kadın iken, 280'i (%52.7) erkek hastaydı. ERH olan hastaların 60'ında (%11.2) hiatal herni, 38'inde (%7.1) Barrett özofagus ve 233'ünde (%43.9) H. pylori pozitif saptandı. ERH hastalarının %66.1'inde evre A, %29.0'unda evre B, %3.9'unda evre C ve %0.9'unda evre D özofajit izlendi. H. pylori varlığı ve özofajit evresi arasında anlamlı bir ilişki yoktu. Sonuç: ERH olan hastaların büyük çoğunluğu düşük evre (evre A ve B) özofajite sahipti. H. pylori'nin özofajit evresine bir etkisi gözlenmedi. H. pylori'nin varlığından ziyade oluşturduğu histolojik gastrit tipi özofajit ile ilişkili olabilir.

The prevelance, endoscopic and histopathological characteristics of erosive reflux disease in endoscopy performed patients and its relationship with Helicobacter pylor

Objectives: Gastroesophageal reflux disease has been defined into three groups of patients: nonerosive reflux disease, erosive reflux disease (ERD), and Barrett's esophagus. The aim of the study was to evaluate the prevelance, endoscopic and histopathological charac- teristics of ERD in endoscopy performed patients and its relationship with Helicobacter pylori infection. Material and methods: Data of the 1840 patients, whom upper gastrointestinal endoscopy was performed and biopsy specimens were obtained from antrum-cor- pus for H. pylori and histopathological examination, were investigated retrospectively. Diagnosis of esophagitis was done based on Los Angles classification criteria. Results: Endoscopically ERD was detected in 531 (28.9%) of 1840 patients. The mean age of the ERD patients was 49.4 ±18.8 years. While 251 (47.2%) of the patients were female, 280 (52.7%) of the patients were male. In patients with ERD, the sliding hiatal hernia and Barrett's esophagus was found in 60 (11.2%) and 38 (7.1%) patients, respectively. In patients with ERH, grade A, B, C and D esophagitis was present in 66.1%, 29.0%, 3.9% and 0.9%, respectively. H. pylori was positive in 43.9% of ERD patients. There was no significant association between the presence of H. pylori and severity of esophagitis. Conclusion: Most of the patients with ERD had low grade (grades A and B) esophagitis. No impact of H. pylori on the severity of esophagitis was shown. The types of histological gastritis caused by H. pylori rather than the presence of H. pylori may associate with esophagitis.

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