Savaş TORLAK, NİLSEL OKUDAN, Hakkı GÖKBEL, MUAZ BELVİRANLI, Aysel KIYICI

Dört haftalık koenzim Q10 desteğinin sedanter genç erkeklerde egzersizle oluşan kas hasarı üzerine etkileri

Amaç: Bu çalışmanın amacı, sedanter genç erkeklerde ekzantrik egzersizin neden olduğu kas hasarında koenzim Q10 (CoQ10) takviyesinin etkilerini incelemekti. Yöntem: Çalışmaya 21 sağlıklı sedanter genç erkek katıldı. Tüm katılımcıların boyları, vücut ağırlıkları ve vücut yağ yüzdeleri ölçüldü ve istirahat kanları alındı. Dört hafta süreyle 11 katılımcıya oral yolla günde tek doz 200 mg CoQ10, 10 katılımcıya plasebo verildikten sonra ölçümler ve kan alımı tekrarlandı. Daha sonra bütün katılımcılara izokinetik egzersiz dinamometresinde ekzantrik egzersiz protokolü uygulandı ve egzersiz sonrası 24. ve 48. saatte kan örnekleri alındı. Alınan kan örneklerinde plazma koenzim Q10 seviyesi, serum kreatin kinaz aktivitesi ve serum miyoglobin seviyesi tayin edildi. Bulgular: Plazma CoQ10 seviyesi CoQ10 takviyesi yapılan grupta plasebo grubuna göre daha yüksekti. Kreatin kinaz aktivitesi ve miyoglobin seviyesi egzersiz sonrası 24. ve 48. saatte her iki grupta da arttı, ama her iki grup arasında anlamlı fark yoktu. Sonuç: Dört haftalık koenzim Q10 takviyesi kan koenzim Q10 seviyesini artırırken egzersizle oluşan kas hasarını etkilemez.

Effects of four week coenzyme Q10 supplementation on exercise-induced muscle damage in sedentary young men

Objective: The purpose of this study was to investigate the effects of coenzyme Q10 (CoQ10) supplementation on eccentric exercise-induced muscle damage in sedentary young males. Methods: Twenty-one sedentary and healthy young male participated to the study. The height, body weight and body fat percentages of the participants were measured and their blood samples were taken at rest. Eleven participants were given 200 mg CoQ10 and ten participants were given placebo orally as a single dosage for four weeks then measurements and blood sampling were repeated. After that eccentric exercise protocol were applied in all participants in isokinetic exercise dynamometry, then their blood samples were taken at 24th and 48th hours after exercise. Plasma coenzyme Q10 levels, serum creatine kinase activities and myoglobin levels were measured in blood samples. Results: Plasma CoQ10 levels were higher in CoQ10 supplemented group compared to placebo group. Creatine kinase activities and miyoglobin levels increased in both groups after exercise but there was no significant difference between the groups. Conclusion: While four weeks of coenzyme Q10 supplementation increase plasma coenzyme Q10 levels, it does not affect creatine kinase activities and myoglobin levels in exerciseinduced muscle damage.

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