Adneksiyel kitle operasyonlarında intraoperatif lidokain’in kusmayı önlemesi

Amaç: Postoperatif kusma (POK), batın içi operasyonlarda sık görülen bir komplikasyondur. Karın ameliyatı geçiren erişkin hastalarda intravenöz lidokain infüzyonu kullanımı POK'yi önleyebilir. Karın içi operasyonlarda genel anesteziye yardımcı olarak kullanılan intravenöz lidokain infüzyonunun anti-emetik etkisini değerlendirmeyi amaçladık. Hastalar: Elektif olarak adneksiyel kitleden opere olan, 30-70 yaşları arasında, ASA I-III erişkin kadınlar seçildi. Müdahale: Anestezinin indüksiyonunu ve idamesini genel olarak onkolojik cerrahi odalarımızda standart hale getirilmiştir. Hastalara rastgele olarak 5 dakika boyunca lidokain (1.5 mg/kg intravenöz lidokain, ardından 2 mg/kgsaat) veya sadece % 0.9 saline (aynı oranda ve hacimde) verildi. İnfüzyonlar ameliyatın sonuna kadar devam edilmiştir. Bulgular: 200 tane adneksiyel kitleden opere olan bayan hasta tarandı. Lidokain grubunda, 100 hastanın 60'ında (% 60) Saline grubunda 100 hastanın 80'inde (% 80) POK görüldü. POK sahibi olma olasılığı, Lidokain alan hastalarda Salin verilen gruba göre% 20 daha az bulundu. Ortalama lidokain plazma konsantrasyonu 4.3 µg/ml idi (0.87 - 4.88). Sonuç: Genel anesteziye yardımcı olarak intravenöz lidokain infüzyonunun kullanılması, elektif adneksiyel kitle operasyonu uygulanan onkoloji hastalarında POBK’yu (Postoperatif Bulantı Kusma) azaltmıştır.

Intraoperative lidocaine prevention of vomiting in adnexal mass operations

Objective: Postoperative vomiting (POV) is a common complication in intra-abdominal operations. The use of intravenous lidocaine infusion in adult patients who underwent abdominal surgery may prevent POV. We aimed to evaluate the anti-emetic effect of intravenous lidocaine infusion used as an adjuvan to general anesthesia in intra-abdominal operations. Patients: ASA I-III adult women aged 30 to 70 years scheduled for elective adnexal mass operations were selected. Intervention: We have standardized the induction and maintenance of anesthesia in our oncological surgery rooms. Patients were randomly administered lidocaine (1.5 mg/kg intravenous (i.v) lidocaine followed by 2 mg/kg/h) or only 0.9% saline (same proportion and volume) for 5 minutes. Infusions were continued until the end of the surgery. Results: 200 women with adnexal mass were operated. In the lidocaine group, 60 (60%) of the 100 patients had POV and 80 (80%) of the 100 patients had POV in the Saline group. The probability of having POV was 20% less in patients receiving lidocaine than in the Saline group. The mean lidocaine plasma concentration was 4.3 µg/ml (range: 0.87 to 4.88). Conclusion: The use of intravenous lidocaine infusion as an adjunct to general anesthesia reduced POVN in oncology patients undergoing elective adnexal mass surgery.

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