Antibacterial Activities of Coordination Compounds Containing Dicyanidoargenta

Our study is on testing of different concentrations (5, 10, 15, 20, 30 and 40 µg/ml) of twelve the newly synthesized bimetallic cyanido complexes ([Ni(hydeten)2Ag(CN)2] [Ag(CN)2].H2O (K1), [Cd2(hydeten)2Ag4(CN)8].H2O (K2), [Ni(bishydeten)2Ag(CN)2] [Ag(CN)2].H2O (K3), [Cu(bishydeten)2Ag2(CN)4] (K4), [Cd(bishydeten)0.5]2[Ag(CN)2]4.3H2O (K5), [Ni(N-bishydeten)Ag3(CN)5] (K6), [Cu(Nbishydeten)Ag3(CN)5] (K7), [Zn(N-bishydeten)Ag3(CN)5] (K8), [Cd(Nbishydeten)]4[Ag(CN)2]8[Ag(CN)]2 (K9), [Cu(edbea)Ag2(CN)4].H2O (K11), [Cd(edbea)2][Ag(CN)2]2.H2O (K12) and [Cd(edbea) Ag3(CN)5] (K13) for their antibacterial activity against Pseudomonas syringae pv. tomato (Pst), Clavibacter michiganensis subsp. michiganensis (Cmm) and Xanthomonas axonopodis pv. vesicatoria (Xav). Antibacterial activity determined using the agar well diffusion assay method.showed that compound K9 has by 90% inhibition ratio on the bacterial growth . Eight out of 12 compounds has over 90% inhibition on Cmm. Inhibitory effects varying between 72% and 100% ratio by K11 and K12 on selected bacterial strains were less than the effects of K9 and K3 which showed highly significant antibacterial activity by 93.83% and 85.71% inhibitions against Pst respectively, whereas the lowest activity was by K4 (33%) treatment at 40 µg/ml against whole bacterial pathogens tested in vitro conditions. On the other hand compound K13 exhibited the highest antibacterial activity against Xav by 99% growth inhibition at 40 µg/ml. Most of these compounds showed promising activities against the tested bacteria. Our further studies will continue on testing of their efficiency under field conditions.

Disiyanidogümüş (I) İçeren Koordinasyon Bileşiklerinin Antibakteriyel Aktiviteleri

Bu çalışmada yeni sentezlenmiş 12 disiyanidogümüş içeren bileşiklerin ([Ni(hydeten)2Ag(CN)2][Ag(CN)2].H2O (K1), [Cd2(hydeten)2Ag4(CN)8].H2O (K2), [Ni(bishydeten)2Ag(CN)2][Ag(CN)2].H2O (K3), [Cu(bishydeten)2Ag2(CN)4] (K4), [Cd(bishydeten)0.5]2[Ag(CN)2]4.3H2O (K5), [Ni(N-bishydeten)Ag3(CN)5] (K6), [Cu(N-bishydeten)Ag3(CN)5] (K7), [Zn(N-bishydeten)Ag3(CN)5] (K8), [Cd(N-bishydeten)]4[Ag(CN)2]8[Ag(CN)]2 (K9), [Cu(edbea)Ag2(CN)4].H2O (K11), [Cd(edbea) 2][Ag(CN)2]2.H2O (K12), ve [Cd(edbea)Ag3(CN)5] (K13) farklı dozlarının (5, 10, 15, 20, 30 and 40 µg/ml) Pseudomonas syringae pv. tomato (Pst), Clavibacter michiganensis subsp. michiganensis (Cmm) ve Xanthomonas axonopodis pv. vesicatoria (Xav) üzerindeki antibakteriyel etkileri belirlenmiştir. Test yöntemi olarak agar kuyucuk difüzyon yöntemi kullanılmıştır. En iyi sonuç K9 maddesinden elde edilmiş olup, bakterilerin koloni gelişimini %90 ve üzerinde engellemiştir. 12 maddeden 8 tanesinin Cmm’in gelişimini %90 ve üzerinde engelledikleri belirlenmiştir. K11 ve K12 maddeleri testlenen bakterileri %72 ile %100 arasında değişen oranlarda engellemişlerdir. Pst üzerinde K9 ve K3 maddeleri sırasıyla %93,83 ve %85,71 oranlarında etkili olurken, en düşük etki 40 µg/ml dozu ile K4 (%33) maddesinde belirlenmiştir. Diğer taraftan Xav üzerinde en yüksek etki %99 oran ile 40 µg/ml dozlu K13 maddesinde görülmüştür. Bu maddelerin çoğunluğunda antibakteriyel etkilerine yönelik ümit var sonuçlar elde edilmiştir. Ancak bu maddelerin tarla koşullarında etkinliklerini belirlemeye yönelik çalışmaların yapılması gerekmektedir.

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