GIDALARDA BULUNAN BİYOJEN AMİNLERİN ÖNEMİ VE DETOKSİFİKASYON MEKANİZMALARI

Günümüzde gıdalarda iz miktarlarda bulunan fakat sağlık açısından önemli etkiler gösteren bileşiklerin belirlenmesi üzerine yapılan çalışmalar devam etmektedir. Biyojen aminler de özellikle proteince zengin gıdalarda ve fermente gıdalarda mikrobiyal dekarboksilasyon veya aldehitlerin ve ketonların deaminasyonu sonucu oluşan ve sağlık açısından birçok etkileri olan bileşikler olarak bu araştırmalara konu olmaktadır. Biyojen aminler vücutta birçok fizyolojik fonksiyonun düzenlenmesinde görev almakla birlikte vücutta yüksek konsantrasyonlarda bulunduklarında ise toksik etki gösterebilmektedirler. Biyojen aminler vücut sisteminde amino oksidaz enzimleri tarafından detoksifiye (katabolize) edilebilmekte olup, bazı durumlarda bu enzimlerin yeterince aktivite gösterememesi sonucu bu aminler vücutta toksik etki gösterebilmektedirler. Bu derlemede, biyojen aminlerin fizyolojik etkileri, toksik etkileri ve detoksifikasyon mekanizmaları güncel literatürler incelenerek tartışılmıştır.

THE IMPORTANCE OF BIOGENIC AMINES IN THE FOODS FOR HEALTH AND THEIR DETOXIFICATION MECHANISMS

Nowadays, the researches about determination of compounds that are present at trace amounts in foods and have significant effects on health have been proceeded. Biogenic amines, which are formed by microbial decarboxylation or deamination of aldehites and ketones, especially in the foods rich in proteins and fermented foods and have many effects on human health, subject to the so-called researches. Biogenic amines play important roles in the regulation of many physiological functions in the body, however excessive intake of biogenic amines could lead to toxicological effects. These amines are detoxified (catabolized) by amine oxidase enzymes in the body, however biogenic amines may cause toxicological effects in cases enzymes at issue are inactivated by some substances. In this review, the physiological and toxicological effects of biogenic amines and their detoxification mechanisms are discussed.

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Kaynak Göster