Tiyosemikarbazon türevleri verilen tavşan karaciğerlerindeki bazı eser elementlerin atomik absorpsiyon spektrofotometresi ile tayini

Bu çalışmada kontrol ve 4 uygulama grubundan oluşan tavşanların karaciğer dokusundaki Ca, Mg, Cu, Zn ve Fe elementleri atomik absorpsiyon spektrofotometresi ile tayin edildi. Uygulama grubu olarak deri altına, 1-(1-mesitil-1-metilsiklobütan-3-il)-2-suksinimido etanon tiyosemikarbazon (MSTSC), 1 -(1 -fenil-1 - metilsiklobütan-3-il)-2-suksinimido etanon tiyosemikarbazon (FSTSC), 1-(1-mesitil-1-metilsiklobütan-3-il)-2- ftalimido etanon tiyosemikarbazon (MFTSC) ve 1-(1 -fenil- l-metilsiklobütan-3-il)-2-ftalimido etanon tiyosemikarbazon (FFTSC) enjekte edilen tavşanlar kullanıldı. Kontrol grubu ile incelenen uygulama grupları istatistiksel olarak karşılaştırıldığında; Cu, Fe ve Zn elementleri bütün gruplarda oldukça önemli ölçüde azaldığı görülmüştür(P0.05), ancak 60 günlük grupta ise önemli olmayan bir azalmanın olduğu gözlendi(P

Determination of some trace elements by atomic absorption spectrophotometry in rabbit liver subject to thiosemicarbazone derivatives

In this study Ca, Mg, Cu, Zn and Fe elements were determined by using flame atomic absorption spectrophotometry(FAAS) in the liver of rabbits, devided in to four experimental groups and control group. Experimental groups injected under the skin of rabbits with 1-(1-mesityl-1-methylcylobutane-3-yl)-2- succinoimido ethanone thiosemicarbazone(MSTSC), 1 -(1 -phenyl-1 -methylcylobutane-3-yl)-2-succinoimido ethanone thiosemicarbazone (FSTSC), 1-(1-mesityl-1-methylcylobutane-3-yl)-2-phthalimido ethanone thiosemicarbazone(MFTSC)and 1 -(1 -phenyl-1 -methylcylobutane-3-yl)-2-phthalimido ethanone thiosemicarbazone (FFTSC). Statistical investigation of the experimental groups with control groups showed that Cu, Fe and Zn concentrations decreased considerable in all groups (P0,05), but 60 days group showed decrased slightly (P

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