Erhan ÖNALAN, Ali Çağrı ORAL, Kübra ORAL, Süleyman AYDIN, AHMET KARATAŞ, Emir DÖNDER

Sklerodermalı Hastalarda Kan ve Tükürükte Sklerostin Düzeyleri

karşılaştırılması ve araştırılmasıdır. Literatürden skleroderma ile sklerostin arasında ilişki olduğunu gösteren yeterli çalışma yapılmadığı anlaşılmaktadır. Sklerostinin skleroderma patogenezinde rol oynayabileceği düşünülmüştür. Gereç ve Yöntem: Çalışmamıza 35 sklerodermalı hasta ile 35 sağlıklı gönüllü alınmıştır. Hasta ve sağlıklı kontrol gruplarında kan ve tükürük sklerostin seviyeleri analiz edildi. Bulgular: Kontrol grubuyla kıyaslandığında, skleroderma grubunda kan ve tükürük sklerostin düzeyleri anlamlı derecede yüksek olarak ölçüldü (p

Sclerostin Levels in Blood and Saliva in Patients with Scleroderma

Objective: Our study aims to investigate and determine the sclerostin levels in blood and saliva of patients with scleroderma (systemıc sclerosis) and to compare their levels with those of healthy volunteers. In the literature, there is no sufficient number of studies that demonstrate the association between scleroderma and sclerostin. Sclerostin is thought to play a role in the pathogenesis of scleroderma. Material and Method: In our study, 35 scleroderma patients and 35 healty volunteers were enrolled. Blood and saliva sclerostin levels of the patient and healthy controls were measured. Results: The level of sclerostin in blood and saliva of the scleroderma group was measured to be significantly higher than in the control group (p

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