Ortalama Trombosit Hacmi Preeklemsi ile İlişkili midir?
Amaç: Bu çalışmada, preeklamptik ve normal gebelerde trombosit parametrelerinin karşılaştırılması amaçlandı. Gereç ve Yöntem: Preeklampsi tanısı almış 50 hasta ve kontrol grubu olarak 70 sağlıklı gebe kadın dahil edildi. Grupların trombosit sayısı ve ortalama trombosit hacmi (OTH) karşılaştırıldı. Bulgular: Preeklampsi grubunda bulunan hastaların yaş ortalaması 28.3± 4.6 yıl ve kontrol grubunda bulunan gebelerin yaş ortalaması 27± 3.5 yıl idi. Her iki grup arasında yaş ortalaması ve gestasyon haftaları yönünden anlamlı fark yoktu (p>0.05). Preeklampsi grubunda ortalama trombosit sayısı (x 103/?L) 235.5±78.5 ve kontrol grubunda bulundu ve gruplar arasında anlamlı fark yoktu (p>0.05). Preeklampsi grubunda ortalama OTH değeri (9.8±1.4) kontrol grubundan (8.7±1.3) anlamlı olarak daha yüksek saptandı (p=0.012). Sonuç: Bu çalışmada OTH değeri preeklampsi grubunda kontrol grubundan daha yüksek bulundu. Ortalama trombosit sayısı ise benzer bulundu.
Is Pre-Eclampsıa Assocıated wıth Mean Platelet Volume
Objective: The aim of this study was to evaluate the platelet parameters in pre-eclamptic and normal pregnant women. Material and methods: Fifty pre-eclamptic women and 70 healthy pregnant women as the control group were enrolled to this study. The platelet count, and mean platelet volume (MPV) of the groups were compared. Results: The mean age of the pre-eclamptic group was 28.3 ± 4.6 year and the control group was 27±3.5 year. There was no statistically signiŞ cant difference between the two groups in terms of the age and gestational weeks (p>0.05). The mean platelet count (x 103/?L) was 235.5±7.5 in the preeclamptic group and in the control group 233.6±38.8 and there was no statistically signiŞ cant difference between the groups (p>0.05). It was found that the MPV value of the pre-eclamptic group was higher than the control group (9.8±1.4 vs. 8.7±1.3, respectively) and there was a statistically signiŞ cant difference between the groups (p=0.012). Coclusion: The mean value of MPV was higher in the pre-eclamptic group than the control group. However, the mean platelet count of the preeclamptic and normal pregnant women were similar.
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- 1. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005; 365: 785-799.
- 2. Roberts JM, Pearson G, Cutler J, Lindheimer M. Summary of the NHLBI working group on research on hypertension during pregnancy. Hypertension 2003; 41: 437-445.
- 3. Pennington KA, Schlitt JM, Jackson DL, Schulz LC, Schust DJ. Preeclampsia: multiple approachesfor a multifactorial disease. Dis Model Mech 2012; 5: 9-18.
- 4. Güven MA, Coşkun A, Ertaş IE, Aral M, Zencirci B, Oksuz H. Association of maternal serum CRP, IL-6, TNF-alpha, homocysteine, folicacidand vitamin B12 levels witht heseverity of preeclampsia and fetal birth weight. Hypertens Pregnancy 2009; 28: 190-200.
- 5. Roberts JM, Taylor RN, Musci TJ, et al. Pre-eclampsia: An Endothelial cell disorder. Am. J. Obstet. Gynecol 1989; 161: 1200-4.
- 6. Iara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of plateletactivity? Clin Appl Thromb Hemost 2003; 9: 177-90.
- 7. Brown AS, Hong Y, de Belder A, et al. Megakaryocyt eploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol 1997; 17: 802-7.
- 8. Dundar O, Yoruk P, Tutuncu L, et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. PrenatDiagn 2008; 28: 1052-1056.
- 9. Ahmed Y, vanIddekinge B, Paul C, Sullivan HF, Elder MG. Retrospective analysis of platelet numbers and volumes in normal pregnancy and in pre-eclampsia. Br J Obstet Gynecol 1993; 100: 216-220.
- 10. Järemo P, Lindahl TL, Lennmarken C, Forsgren H. Theuse of platelet density and volume measurements to estimatet heseverity of pre-eclampsia. Eur J ClinInvest 2000; 30: 1113- 1118.
- 11. Neiger R, Contag SA, Coustan DR. Preeclampsia effect on platelet count. Am J Perinatol 1992; 9: 378-380.
- 12. Makuyana D, Mahomed K, Shukusho FD, Majoko F. Liver and kidney function tests in normal and pre-eclamptic gestation--a comparison with non gestational reference values. Cent Afr J Med 2002; 48: 55-59.
- 13. Boriboonhirunsarn D, Atisook R, Taveethamsathit T. Mean platelet volume of normal pregnant women and severe preeclamptic women in Siriraj Hospital. J Med Assoc Thai 1995; 78: 586-589.
- 14. Ceyhan T, Beyan C, Başer İ, Kaptan K, Güngör S, Ifran A. Theeffect of pre-eclampsia on complete blood count, platelet count and platelet volume. Ann Hematol 2006; 85: 320-322.
- 15. Holthe MR, Staff AC, Berge LN, Lyberg T. Different levels of platelet activation in preeclamptic, normotensive pregnant, and nonpregnant women. Am J Obstet Gynecol 2004; 190: 1128- 1134.
- 16. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 2003; 102: 181- 192.
- 17. Report of the National High Blood Pressure Education Program Working Group. Report on high blood pressure in pregnancy. Am J Obstet Gynecol 2000; 183: 1-22.
- 18. Edelstam G, Lowbeer C, Kral G, Gustafsson SA, Venge P. New reference values for routine blood samples and human neutrophilic lipocalin during third-trimester pregnancy. Scand J Clin Lab Invest 2001; 61: 583-592.
- 19. Lurie S, Rigini N, Zabeeda D, Sadan O, Ezri T, Glezerman M. Changes in platelet function, volume and count during laborand 24 hours postpartum. Platelets 2003; 14: 355-35
- 20. James TR, Reid HL, Mullings AM. Are published standards for haematological indices in pregnancy applicable across populations: an evaluation in healthy pregnant Jamaican women. BMC Pregnancy Child birth 2008; 8: 8.
- 21. Akingbola TS, Adewole IF, Adesina OA, et al. Haematological profile of healthy pregnant women in Ibadan, south-western Nigeria. J Obstet Gynecol 2006; 26: 763-769.
- 22. Bessman JD, Williams LJ, Gilmer PR Jr. Mean platelet volume. The inverserelation of platelet size and count in normal subjects, and an artifact of otherparticles. Am J Clin Pathol 1981; 76: 289- 293.
- 23. Bessman JD, Williams LJ, Gilmer PR Jr. Platelet size in health and hematologic disease. Am J Clin Pathol 1982; 78: 150-153.
- 24. Bessman JD, Gilmer PR, Gardner FH. Use of mean platelet volume improves detection of platelet disorders. Blood Cells 1985; 11: 127-135.
- 25. Ryan N. Platelet indices during normal pregnancy and preeclampsia. Br J Biomed Sci 1999; 56: 20-22.
- 26. Gioia S, Piazze J, Anceschi MM, et al. Mean platelet volume: association with adverse neonatal outcome. Platelets 2007; 18: 284-288.