Neutrophil to Lymphocyte Ratio: A Simple and Readily Available Independent Marker of Mortality in Acute Ischemic Stroke

Nötrofil Lenfosit Oranı: Akut İskemik İnmede Mortalitenin Basit, Kolay ve Bağımsız Belirteci Amaç:Akut iskemik inme nedeniyle başvuran hastalarda nötrofil/lenfosit oranının (NLR) prognostik değerini belirlemek için bu çalışma yapıldı. Gereç ve Yöntem: Ocak ve Haziran 2014 tarihleri arasında Ankara Numune Eğitim ve Araştırma Hastanesi ve Ankara Eğitim ve Araştırma Hastanesi nöroloji kliniğine başvuran Hastalar geriye dönük olarak incelendi, 209 akut iskemik inme (AIS) hastası ve 202 kontrol grubu incelendi. Sağlık inme ölçeği skoru (NIHSS) ve inme alt tiplerini belirlemek için TOAST ve Bamford sınıflaması kullanıldı. Modifiye Rankin Skalası (mRS) kullanarak fonksiyonel değerlendirme ve ölüm sonuçları 3. ayda değerlendirildi. Bulgular: Hastaların yaş ortalaması 68.5±13.9 olarak belirlendi (106 erkek ve 103 kadın). AIS grubunda (4.00±3.76) kontrol grubuna (2.18±0.99) göre NLR anlamlı olarak yüksek bulundu (p =16 puan hastalarda, NLR ve Mean Platelet Volüm (MPV) düzeyleri NIHSS

Nötrofil Lenfosit Oranı: Akut İskemik İnmede Mortalitenin Basit, Kolay ve Bağımsız Belirteci

O bje ctive: We performed this study to identify the prognostic value of neutrophil/lymphocyte ratio (NLR) in patients presenting with acute ischemic stroke (AIS). Mate rial and Method: We retrospectively analyzed 209 consecutive AIS patients and 202 age and sex matched healthy control subjects admitted to neurology clinics of Ankara Numune Training and Research Hospital and Ankara Training and Research Hospital between January and June 2014. Patients were classified into admission National Institute of Health Stroke Scale (NIHSS) score strata, and stroke subtypes were classified using T rial of Org 10172 in Acute Stroke Treatment (TOAST) and Bamford classifications. Mortality and functional outcome using modified Rankin Scale (mRS) was determined at 3 months. Re sults: The mean age of patients was 68.5±13.9 years (106 men and 103 women). NLR was significantly higher in AIS group (4.00±3.76) compared to control group (2.18±0.99) (p <0,001). In patients with NIHSS>=16, NLR and mean platelet volume (MPV9) levels were significantly higher compared with moderate and mild (<=5) NIHSS score group (p <0.001 and p =0.001, respectively). CRP levels were significantly higher in severe and moderate group (p <0.001). When patients are grouped according to functional outcomes at 3 months, NLR levels were significantly higher in patients who died (p =0.001) and CRP levels were significantly higher in patients who died and those with unfavorable outcome groups ( p <0.001). C onclusion: NLR may be used as a simple and easy-to-measure independent marker for prediction of mortality in acute ischemic stroke patients.

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