Metabolik Kompozisyonların Diyabetik Ayak Ülseri Gelişimindeki Etkileri

Amaç: Diyabet, tüm dünyada olduğu gibi ülkemizde de epidemik denilebilecek oranlara ulaşmıştır. Diyabetik hastalarda ayak ülserleri yalnızca bir ülser ya da diyabet olarak algılanmayıp vücudun metabolik kompozisyonlarındaki değişiklikler ile bağlantılı olabilir. Dolayısı ile bu çalışmada sağlıklı (kontrol), diyabetik ayak ülserli (DAÜ) ve ülsersiz diyabetik hastaların (ÜDH) demografik özellikleri, antropometrik ölçümleri ve bazı biyo-kimyasal parametrelerinin birbiri ile kıyaslanması amaçlandı. Gereç ve Yöntem: Fırat Üniversitesi Hastanesi Endokrinoloji ve Metabolizma Hastalıkları Polikliniğine başvuran 26 DAÜ’lü, 34 ÜDH ve 30 kontrol olmak üzere toplam 90 birey dahil edildi. DAÜ grubu Wagner sınıflandırmasına göre değerlendirildi. Bu bireylerin vücut kitle indeksi (VKİ), boyun, bel, kalça çevre ölçümleri, açlık kan şekeri, HbA1c, lipid profili, aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), albümin, üre, kreati-nin düzeyleri hasta kayıtlarından elde edildi ve TANİTA cihazı ile vücut kompozisyon analizi saptandı. Bulgular: Yağ oranı; DAÜ’lü grupta (%27,4), ÜDH grubunda (%33,9), kontrol grubunda (%22,3) (p

Effects of Metabolic Compositions on the Development of Diabetic Foot Ulcers

Objective: Diabetes has become epidemic not only in our country but also all over the world. Foot ulcers in diabetic patients should be considered not only as an ulcer or a complication of diabetes but also as changes in the metabolic composition of the body. Therefore, it is aimed, to compare the demographic characteristics, anthropometric measurements and some biochemical parameters of healthy controls, diabetic foot ulcer patients (DFUP) and non-ulcer diabetic patients (NUDP) in this study. Material and Method: A total of 90 individuals, 26 DFUP, 34 NUDP and 30 healthy controls were included. The DFUP group was evaluated ac-cording to the Wagner classification.Body mass index (BMI), neck, waist and hip circumference, fasting blood sugar level, HbA1c, lipid profile, aspartat aminotransferase (AST), alanin aminotransferase (ALT), albumin, urea and creatinine levels were obtained from patient database and body composition analysis was detected by using TANITA device. Results: It is reported that proportion of fat was 27.4% in DFUP group, 33.9% in the NUDP group and 22.3% in the control group. Lipid profile measures in the DFUP group were significantly lower than the other two groups. It is observed that in the DFUP group, the Wagner score increases as the BMI (p =0,452), waist circumference (p =0,848) and hip circumference (p =0,614) decreases. Also, in DFUP patients, an increase in the amount of urea and decrease in the albumin were reported. Conclusion: Decrease in fat, albumin and lipid profile measures and increase in urea levels in DFUP patients indicate that these parameters play a role in the etiopathology of this disease. Therefore, we conclude that keeping the body fat composition close to ideal values in the diabetic patient group may have a protective role against DFUP formation.

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