Caner Feyzi DEMİR, RABİA BİLİCİ, Hasan Hüseyin ÖZDEMİR, Said BERİLGEN

Major depresyonlu hastalarda elektrokonvulsiv terapinin sempatik deri yanıtı üzerine etkileri

Amaç: Depresif hastalar sıklıkla vejetatif semptomlardan yakınmaktadırlar. Depresyon ve otonom regülasyon bozuklukları arasındaki ilişki uzun zamandan beri bilinmektedir. Bu çalışmanın amacı major depresyonu olan hastalarda elektrokonvulziv terapi ile (EKT) sempatik deri yanıtlarının (SDY) etkilenip etkilenmediğini değerlendirmektir. Gereç ve Yöntemler: Çalışmamızda tedavi sürecinde EKT yapılacak major depresyonu olan 40 hasta ve 30 sağlıklı kişi incelendi. Sempatik deri yanıtları EKT nin uygulandığı aynı gün içerisinde EKT uygulanmasından önce ve sonra değerlendirildi. Elektrokonvulziv terapi öncesi, EKT sonrası ve kontrol grubuna ait SDY ölçümleri nonparametrik testlerle karşılaştırıldı. Bulgular: Major depresyonu olan hastalarda EKT sonrası SDY latans ortalaması (1.25±0.11 ms) EKT öncesi SDY latans ortalamasından (1.26± 0.11 ms) istatistiksel olarak anlamlı ölçüde farklı bulundu (p

Effects of electroconvulsive therapy on sympathetic skin responses in patients with major depression

Objective: Depressed patients frequently complain about vegetative symptoms. The relation between depression and disturbances of autonomic regulation has been recognised for a long time. The aim of this study was to investigate whether sympathetic skin responses (SSRs) were affected by electroconvulsive therapy (ECT) in patients with major depression. Materials and Methods: In our study we examined 40 patients diagnosed with major depression who would take ECT during a course of treatment and 30 age-matched healthy subjects. Sympathetic skin responses were assesed on the same day before and after the ECT. Pre-ECT, post-ECT, and control groups' measurements of SSR were compared by non-parametric tests. Results: The mean post-ECT latency of SSR (1.25±0.11 ms) was statistically significantly different (p <0.05) compared with pre-ECT latency of SSR (1.26± 0.11 ms) in patients with major depression. This result demonstrates a relation between SSR and ECT in patients with major depression. However there was no significant difference in SSR latency between patients (pre-ECT and post-ECT) and controls (1.22±0.08 ms). There was no statistically difference also in SSR amplitude among three groups. Conclusion: Data reported in this article support that activation of sympathetic system by ECT treatment does not have a major efficacy in patients with major depression. More studies are needed to evaluate the effects of depression treatment with ECT on SSR.

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