Histerektomi materyallerinde histopatolojik tanıların insidansı

Amaç: Bu çalışmada histerektomi için klinik endikasyonların sıklığı ve histerektomi materyallerindeki en yaygın patolojiler tanımlandı. Gereç ve Yöntem: Ekim 2007 ile Ekim 2009 arasında 361 histerektomi materyali tekrar gözden geçirildi ve patolojik tanılar araştırıldı. Bulgular: Histerektomi için en yaygın klinik endikasyon leiomyoma (% 31.85) idi. Diğer klinik endikasyonlar endometrial hiperplazi (% 27.14), disfonksiyonel uterin kanama (% 18.55), uterus prolapsusu (% 9.14), kronik pelvik ağrı (% 7.20), adenomyozis (% 3.87), servikal neoplazi (% 2.21) idi. En yaygın tanımlanan patoloji leiomyoma (% 40.16) idi. Diğer patolojiler endometrial hiperplazi (% 38.22), adenomyozis (% 25.48), endometrial polipler (% 8.86), CIN 1 ( % 3.32 ), CIN 2 ( % 1.66 ) ve atrofik endometrium (% 3.60) idi. Yüzellisekiz (% 43.76) histerektomi materyalinde kombine patolojiler tanımlandı. En yaygın kombinasyon leiomyoma ve endometrial hiperplazi (% 38.60) idi. Diğer kombine patolojiler adenomyozis ve endometrial polip (% 17.72), adenomyozis ve leiomyoma (% 12.65), leiomyoma ve endometrial polipler (% 8.22) idi. Sonuç Endometrial patolojiler nedeniyle özellikle premenapozal ve postmenapozal dönemde opere edilecek olgularda servikal neoplazilerin beraber olabileceği unutulmamalıdır. Bu nedenle endometrial örnekleme yaparken endoservikal örneklemeninde yapılması önemlidir.

The ıncidence of histopathologic diagnosis in hysterectomy specimens

Objective: This study identified the frequency of clinical indications for hysterectomy and the most common pathologies in hysterectomy specimens. Material and Methods: A total of 361 hysterectomy specimens between October 2007 and October 2009 were retrieved and studied Results: The most common indication for hysterectomy was leiomyoma (31.85 %). Other indications were endometrial hyperplasia (27.14 %), dysfunctional uterine bleeding (18.55 %), uterine prolapse (9.14 %), chronic pelvic pain (7.20 %), adenomiyosis (3.87 %), cervical neoplasia (2.21 %). The most common pathology identified was leiomyoma (40.16 %). Other pathologies included endometrial hyperplasia (38.22 %), adenomyosis (25.48 %), endometrial polyps (8.86 %), CIN 1 (3.32 %), CIN 2 (1.66 %) and atrophic endometrium (3.60 %). In 158 (43.76 %) of hysterectomy specimens combined pathology was identified. The most common combination was leiomyoma and endometrial hyperplasia (38.60%). Other combined pathologies included adenomoysis and endometrial polyps (17.72 %), adenomyosis and leiomyoma (12.65 %), leiomyoma and endometrial polyps (8.22 %). Conclusion: The existence of cervical disorders should be demonstrated when an operation is going to be performed for an endometrial pathology in a pre or postmenopausal woman. Cervix and cervical canal should be examined during endometrial evaluation.

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  • 1. Marana R, Paparella PL, Catalano GF, Caruana P, Pedulla S, mancuso S. Laparoscopically assisted vaginal hysterectomy as an alternative to abdominal hysterectomy. Gynecol Obstet Invest 1996; 42: 249-252.
  • 2. Bren L. Alternative to hysterectomy: new technologies, more options. FDA Consumer. Rockville 2001; 35; 23.
  • 3. Marana R, Busacca M, Zupi E, Garcea N, Paparella PL,Catalano GF. Laparoscopically assisted vaginal hysterectomy versus total abdominal hysterectomy: A prospective, randomized, multicenter study. Am J Obstet Gynecol 1999; 180: 270-275.
  • 4. Coulter A, Bradlow J, Agass M, Martin-Bates C, Tulloch A. Outcomes of referrals to gynaecology outpatient clinics for menstrual problems: an audit of general practice records. Br J Obstet Gynaecol 1991; 98: 789-796.
  • 5. Vessey MP, Villard-Mackintosh L, McPherson K, Coulter A, Yeats D. The epidemiology of hysterectomy: findings in a large cohort study. Br J Obstet Gynecol 1992; 99: 402-407.
  • 6. Carlson K, Nichols D, Schiff I. Indication for Hysterectomy. N Engl J Med 1993; 328: 856-860.
  • 7. Shegill SK, Shergill HK. Clinicopathological study of hysterectomies. J Indian Med Assoc 2002; 100: 238-239.
  • 8. Ojeda VJ. The pathology of hysterectomy specimens. Z Med J 1979; 89: 169-171.
  • 9. Arif A, Jamal S, Mubarik A, Zubair A, Ghori UK. Study of adenomyosis in different decades of life: An experience at army medical college, Rawalpindi-Pakistan. Pak J Pathol 2007; 18: 75-78.
  • 10. Lee NC, Dicker RC, Rubin GL, Ory HW. Confirmation of the preoperative diagnoses for hysterectomy. Am J Obstet Gynecol 1984; 150: 283-287.
  • 11. Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update 1998; 4: 312-322.
  • 12. Leyendecker G, Wildt L, Mall G. The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. Arch Gynecol Obstet 2009; 280: 529-538.
  • 13. Bird CC, McElin TW, Manalo-Estrella P. The elusive adenomyosis of the uterus-revisited. Am J Obstet Gynecol 1972; 112: 583-593.
  • 14. K. Jo. Adenomyosis: the pathophysiology of an oestrogen-dependent disease. Best Pract Res Clin Obstet Gynecol 2006; 20: 493-502.
  • 15. Atri M, Reinhold C, Mehio AR, Chapman WB, Bret PM. Adenomyosis: US features with histologic correlation in an in vitro study. Radiology 2000; 215: 783-790.
  • 16. Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect 2003; 111: 1037- 1054.
  • 17. Sherman ME, Mazur MT, Kurman RJ. Benign diseases of the endometrium. In: Kurman RJ, editor. Blaunstein’s pathology of the female genital tract. 5. edition. New York: Springer, 2002; 421–466.
  • 18. Perez-Medina T, Martinez O, Folgueira G, Bjo J. Which endometrial polyps should be resected? J Am Assoc Gynecol Laparosc 1999; 6: 71-74.
  • 19. Reslova T, Tosner J, Resl M, Kugler R, Vavrova I. Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet 1999; 262: 133-139.
  • 20. Talukder SI, Haque MA, Hug MH, Alam MO, Roushan A, Noor Z, et al. Histopathological analysis of hysterectomy specimens. Mymensing Med J 2007; 16: 81-84.
  • 21. Bukhari U, Sadiq S. Analysis of the underlying pathological lesions in hysterectomy specimens. Pak J Pathol 2007; 18: 110-112.
  • 22. Verit FF, Artuc H, Kafalı H. The evaluation Of Simple Hysterectomies At Harran University Department Of Obstetrics And Gynecology. Türkiye Klinikleri J Gynecol Obst 2006; 16: 77-81.
  • 23. Sutton GP, Brill L. Malignant papillary lesion of the endometrium. Gynecol Oncol 1987; 27: 294-304.
  • 24. Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long term study of 'untreated' hyperplasia in 170 patients. Cancer 1985; 56: 403-412.
  • 25. Tabata T, Yamawaki T, Yabana T, Ida M, Nishimura K, Nose Y. Natural history of endometrial hyperplasia: study of 77 patients. Arch Gynecol Obstet 2001; 265: 85-88.
  • 26. Janicek MF, Rosenshein NB. Invasive endometrial cancer in uteri resected for atypical endometrial hyperplasia. Gynecol Oncol 1994; 52: 373-378.
Fırat Tıp Dergisi-Cover
  • ISSN: 1300-9818
  • Başlangıç: 2015
  • Yayıncı: Fırat Üniversitesi Tıp Fakültesi