Diyabetes mellituslu hastalarda santral kornea kalınlığının değerlendirilmesi

Amaç: Diyabetes mellituslu (DM) hastalarda ve sağlıklı bireylerde santral kornea kalınlığının (SKK) değerlendirilmesi. Gereç ve Yöntemler: Diyabetes mellitus tanısı ile kliniğimizde diyabetik retinopati açısından takip edilen 50 hastanın 100 gözü çalışma kapsamına alındı. Hastalar diyabetik retinopatisi olan (grup 1, 19 hasta) ve diyabetik retinopatisi olmayan (grup 2, 31 hasta) olarak iki gruba ayrıldı. Poliklinik muayenesine gelen DM si olmayan, sağlıklı 50 hastanın 100 gözü kontrol grubu (grup 3) olarak seçildi. Tüm gruplara ayrıntılı oftalmolojik muayene yapıldı. Kornea patolojisi ve daha önceden geçirilmiş cerrahi öyküsü olan hastalar çalışma kapsamına alınmadı. Tüm hastaların SKK'sı topikal anestezi altında ultrasonik pakimetri cihazı (Optopol, Echoson Demsin M, Poland ) ile ölçüldü. Bulgular: DM'li hastaların ortalama santral kornea kalınlığı 548.94±37.13 µm; kontrol grubunun ortalama santral kornea kalınlığı 533.45±43.38 µm idi. Santral kornea kalınlığı DM'li hastalarda kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı derecede yüksek bulundu (p< 0.05). Diyabetik retinopatisi olan grubun (grup 1) santral kornea kalınlığı 558.39 ± 29.8 µm, diyabetik retinopatisi olmayan grubun (grup 2) santral kornea kalınlığı 543.14±40.1 µm idi. Bu iki gup arasında yapılan istatistiksel değerlendirmede diyabetik retinopatisi olan hastaların santral kornea kalınlığı retinopatisi olmayan hastalara göre anlamlı derecede yüksek bulundu (p

Evaluation of central corneal thickness in patients with diabetes mellitus

Objective: To evaluate the central corneal thickness (CCT) in patients with diabetes mellitus (DM) and healty control subjects. Materials and Methods: A hundred eyes of fifty patients with DM followed up in our clinic were investigated in the study. The diabetics were divided into two groups as having diabetic retinopathy (group 1, 19 patients) and not (group 2,31 patients), and a hundred eyes of 50 non-diabetic, healty subjects were classified as control group (group 3). All the patients SKK was measured via ultrasonic pachymeter (Optopol, Echoson Demsin M, Poland) under topical anesthesia. Results: The mean CCT was found as 548.94±37.13 µm in patients with DM; 533.45±43.38 µm in healty control group. The difference between diabetic patients and healty subjects was statistically significiant (p < 0.05). The mean CCT in patients with diabetic retinopathy (group 1) was 558.39±29.8 µm, and in non-diabetic retinopathy group (group 2), the mean CCT was found 543.14±40.1 µm. The difference between group 1 and 2 was statistically significiant (p<0.05). Conclusion: We found that diabetic patients had an increased central corneal thickness when compared with healty control subjects. Furthermore, retinopathy increases the relevance of thicker cornea in diabetic patients.

___

  • 1) Goebbels M: Tear secretion and tear film function in insulin dependent diabetics. Br J Ophthalmol 2000; 84: 19-21.
  • 2) Seifart U,Strempel I: The dry eye and diabetes mellitus. Ophthalmologe 1994; 91: 235-239.
  • 3) Goebbels M, Spitznas M. Endothelial barrier function after phacoemulsification: a comparison between diabetic and non-diabetic patients. Graefes Arch Clin Exp Ophthalmol 1991; 229: 254-257.
  • 4) Jeng S, Lee JS, Huang SC. Corneal decompensation after argon laser iridectomy-a delayed complication. Ophthalmic Surg 1991; 22: 565-569.
  • 5) Larsson LI, Bourne WM, Pach JM, Brubaker RF. Structure and function of the corneal endothelium in diabetes mellitus type I and type II. Arch Ophthalmol 1996; 114: 9-14.
  • 6) Bron AM, Creuzot-Garcher C, Goudeau-Boutillon S, d'Athis P. Falsely elevated intraocular pressure due to increased central corneal thickness. Graefes Arch Clin Exp Ophthalmol 1999; 237: 220-224.
  • 7) Inoue K, Kato S, Inoue Y, Amano S, Oshika T. The corneal endothelium and thickness in type II diabetes mellitus. Jpn J Ophthalmol 2002; 46: 65-69.
  • 8) Roszkowska AM, Tringali CG, Colosi P, Squeri CA, Ferreri G. Corneal endothelium evaluation in type I and type II diabetes mellitus. Ophthalmologica 1999; 213: 258-261.
  • 9) Ravalico G, Tognetto D, Palomba M, Calderini S, Vattovani O. Corneal endothelial function in diabetes: a fluorophotometric study. Ophthalmologica 1994; 208: 179-184.
  • 10) Busted N, Olsen T, Schmitz O. Clinical observations on the corneal thickness and the corneal endothelium in diabetes mellitus. Br J Ophthalmol 1981; 65: 687-690.
  • 11) Brandt JD, Beiser JA, Kass MA, Gordon MO. Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS). Ophthalmology 2001; 108: 1779-1788.
  • 12) Nemesure B, Wu SY, Hennis A, et al. Corneal thickness and intraocular pressure in the Barbados eye studies. Arch Ophthalmol 2003; 121: 240-244.
  • 13) Lee JS, Oum BS, Choi HY, Lee JE, Cho BM. Differences in corneal thickness and corneal endothelium related to duration in diabetes. Eye 2006; 20: 315-318.
  • 14) Ermis SS, Ermis F, Ersanlı D, Sönmez M, Ünal M, Gülecek O. Đnsüline bağımlı diyabetes mellitusda santral kornea kalınlığı. MN-Oftalmoloji 2001; 8: 369-371.
  • 15) Güngel H, Đnal B, Tuygun Z, Kapran Z. Tip II diabetes mellituslu hastalarda santral kornea kalınlığını etkileyen faktörler. T. Oft. Gaz 2002; 32: 468-472.
  • 16) Keoleian GM, Pach JM, David OH, et al. Structural and functional studies of the corneal endothelium in diabetes mellitus. Am J Ophthalmol 1992; 113: 64-70.
  • 17) Schultz RO, Matsuda M, Yee R, et al. Corneal endothelial changes in type 1 and 2 diabetes mellitus. Am J Ophthalmol 1984; 98: 401-410.
  • 18) Bayraktar MZ, Yıldırım E, Karagül S, et al. Diyabetik retinopatili olgularda endotel değişikliklerinin speküler mikroskopi ile değerlendirilmesi.TODXX. Ulusal Kongresi, 1989, Bursa. Kongre Özet Kitabı, 522-526.
  • 19) McNamara NA, Brand RJ, Polse KA, Bourne WM. Corneal function during normal and high serum glucose levels in diabetes. Invest Ophthalmol Vis Sci 1998; 39: 3-17.
  • 20) Weston BC, Bourne WM, Polse KA, Hodge DO. Corneal hydration control in diabetes mellitus. Invest Ophthalmol Vis Sci 1995; 36: 586-595.
  • 21) Olsen T, Busted N. Corneal thickness in eyes with diabetic and nondiabetic neovascularization. Br J Ophthalmol 1981; 65: 691-693.
  • 22) Herse PR. Corneal hydration control in normal and alloxaninduced diabetic rabbits. Invest Ophthalmol Vis Sci 1990; 31: 2205-2213.
Fırat Tıp Dergisi-Cover
  • ISSN: 1300-9818
  • Başlangıç: 2015
  • Yayıncı: Fırat Üniversitesi Tıp Fakültesi