Baş veboyuntümörlerinde positron emisyontomografi/bilgisayarlı tomografi (pet/bt)

Amaç: Baş ve boyun tümörlerinde evrelemede PET/BT giderek artan oranda rutin kullanıma girmektedir. PET/BT tüm vücudu tarama olanağı sağlaması ve baş-boyun tümörlerinde tutulum göstermesi ve lenf nodlarını doğru bir şekilde karakterize etmesi bakımından evrelemede kolaylık sağlamaktadır. Bu çalışma ile baş ve boyun tümörleri olan hastalarda evrelemede PET/BT’nin önemini araştırdık. Gereç ve Yöntem: Çalışmaya baş ve boyun tümörü olan 19 hasta (11 E, 8 K; ortalama yaş;50.4±17) dahil edilmiştir. Hastalara yapılan PET/BT sonuçları altın standart takip sonucu veya histopatoloji alınarak değerlendirilmiştir. Bulgular: Çalışmaya dahil edilen hastalardan 3 tanesi tiroid karsinomu, 3’ünde larenks karsinomu, 1’inde boyunda lenfadenopati etyolojisi, 3’ünde dil-damakta kitle, 3’ünde boyunda kitle karakterizasyonu, 2’sinde proksimal özefagus karsinomu, 3’ünde parotis tümörü ve 1 hastada yüzde malign melanom nedeniyle PET/BT yapılmıştır. PET/BT hastalardan 4 tanesinde rezidü/nüks ve 9’unda kitle lezyonu tanımlamış, 5’inde lenf nodu yayılımını ve bir hastada rezidü veya nüks olmadığını göstermiştir. Bütün hasta grubunda toplam 11 hastada lenf nodu invazyonu ve 6 hastada uzak metastazı göstermiştir. Patolojik lenfadenopati nedeniyle gönderilen bir hastada ise primeri belirleyememiştir. Sonuç: PET/BT baş boyun tümörlerinin değerlendirilmesinde rahatlıkla kullanılabilecek bir yöntemdir. Yöntemin gerek bu bölgeye özgü gerekse genel sınırlılıkları göz önünde bulundurularak yüksek doğrulukla kitle tanımlama ve evreleme için kullanılabilir. Baş boyun tümörleri, PET/BT, Evreleme.

Positron emission tomography/computerized tomography (pet/ct) in head and neck tumors

Objective: PET/CT is gaining acceptance in staging head and neck tumors in routine practice. Capability of PET/CT to scan whole body, affinity to head and neck tumors and accurate characterization of lymph nodes makes staging easier with PET/CT. In this study, we investigated the importance of PET/CT in staging of head and neck tumors. Materials and Methods: Nineteen patients with head and neck tumors (11 M, 8 F; mean: 50,4±17 years old) were included to the study. PET/CT results of patients were evaluated with follow-up results or histophology as the gold standard. Results: The patients were presented as thyroid carcinoma 3, laryngeal carcinoma 3, etiology of lymphadenopathy 1, lip or palatal tumor 3, mass characterization 3, proximal esophagus carcinoma 2, parotis tumor 3 and facial malign melanoma 1 patient. PET/CT identified residual or recurrent tumor in 4 patients, mass in 9, lymph node invasion in 5 and in one patient no residual disease. In whole group total 11 lymph node invasion and 6 distant metastasis were identified. Primary site of patient who had lymph node metastasis weren’t found with PET/CT. Conclusion: Because of the capability of whole body definition and accurate lymph node staging of PET/CT and remarkable FDG affinity of head and neck tumors, PET/CT is a preferable imaging method. Considering general limitations and limitations which are specific to head and neck region of PET/CT; PET/CT can be used for staging and identification of head and neck tumors with high accuracy.

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  • 1.Schwartz DL, Rajendran J, Yueh B, et al. Staging of head and neck squamous cell cancer with extended-field FDG- PET.Arch Otolaryngol Head Neck Surg 2003; 129: 1173- 1178.
  • 2.Dennington ML, Carter DR, Meyers AD. Distant metastases in head and neck epidermoid carcinoma. Laryngoscope 1980; 90: 196-201.
  • 3.Black RJ, Gluckman JL, Shumrick DA. Screening for distant metastases in head and neck cancer patients. Aust N Z J Surg 1984; 54: 527-530.
  • 4.Kumar R, Mavi A, Bural G, Alavi A. Fluorodeoxyglucose- PET in the management of malignant melanoma. Radiol Clin North Am 2005; 43: 23-33.
  • 5.Kitagawa Y, Nishizawa S, Sano K, et al. Prospective compari- son of 18F-FDG PET with conventional imaging modalities (MRI, CT, and 67Ga scintigraphy) in assessment of combined intraarterial chemotherapy and radiotherapy for head and neck carcinoma. J Nucl Med 2003; 44: 198–206.
  • 6.Di Martino E, Nowak B, Hassan HA, et al. Diagnosis and staging of head and neck cancer: a comparison of modern imaging modalities (positron emission tomography, computed tomography, color-coded duplex sonography) with panendos- copic and histopathologic findings. Arch Otolaryngol Head Neck Surg 2000; 126: 1457-1461.
  • 7.Basu D, Siegel BA, McDonald DJ, Nussenbaum B. Detection of occult bone metastases from head and neck squamous cell carcinoma: impact of positron emission tomography computed tomography with fluorodeoxyglucose F 18. Arch Otolaryngol Head Neck Surg 2007; 133: 801-805.
  • 8.Gordin A, Daitzchman M, Doweck I, et al. Fluoro- deoxyglucose-positron emission tomography /computed to- mography imaging in patients with carcinoma of the larynx: diagnostic accuracy and impact on clinical management. Laryngoscope 2006; 116: 273-278.
  • 9.Ha PK, Hdeib A, Goldenberg D, et al. The role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2006; 132: 12-16.
  • 10.Schoder H, Yeung HW, Gonen M, et al. Head and neck can- cer: clinical usefulness and accuracy of PET/CT image fusion. Radiology 2004; 231: 65–72.
  • 11.Demirci U, Coskun U, Akdemir UO, et al. The Nodal Stan- dard Uptake Value (SUV) as a Prognostic Factor in Head and Neck Squamous Cell Cancer. Asian Pac J Cancer Prev 2011; 12: 1817-1820.
  • 12.Liao CT, Wang HM, Huang SF, et al. PET and PET/CT of the neck lymph nodes improves risk prediction in patients with squamous cell carcinoma of the oral cavity. J Nucl Med 2011; 52: 180-187.
  • 13.Connell CA, Corry J, Milner AD, et al. Head Neck. Clinical impact of, and prognostic stratification by, F-18 FDG PET/CT in head and neck mucosal squamous cell carcinoma. Head Neck 2007; 29: 986-995.
  • 14.Haerle SK, Schmid DT, Ahmad N, Hany TF, Stoeckli SJ. The value of (18) F-FDG PET/CT for the detection of distant me- tastases in high-risk patients with head and neck squamous cell carcinoma. Oral Oncol 2011; 47: 653-659.
  • 15.Xu GZ, Guan DJ, He ZY. (18) FDG-PET/CT for detecting distant metastases and second primary cancers in patients with head and neck cancer. A meta-analysis. Oral Oncol 2011; 47: 560-565.
  • 16.Law A, Peters LJ, Dutu G, Rischin D, Lau E, Drummond E, Corry J. The utility of PET/CT in staging and assessment of treatment response of nasopharyngeal cancer. J Med Imaging Radiat Oncol 2011; 55: 199-205.
  • 17.Kim SY, Kim JS, Doo H, et al. Combined [18F] fluoro- deoxyglucose positron emission tomography and computed tomography for detecting contralateral neck metastases in pa- tients with head and neck squamous cell carcinoma. Oral On- col 2011; 47: 376-380.
  • 18.Maldonado A, González-Alenda FJ, Alonso M, Sierra JM. PET/CT in clinical oncology. Clin Transl Oncol 2007; 9: 494- 505.
Fırat Tıp Dergisi-Cover
  • ISSN: 1300-9818
  • Başlangıç: 2015
  • Yayıncı: Fırat Üniversitesi Tıp Fakültesi
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