Apendektomi Materyallerinde Saptanan Histopatolojik Tanılar

Amaç: Bu çalışmada, Yozgat yöresinde akut karın semptomları nedeni ile apendektomi yapılan hastalarda saptanan histopatolojik tanıları belirlemek ve insidanslarını araştırmak amaçlandı. Gereç ve Yöntem: Yakın zamanda kurulmuş bir üniversite olan Bozok Üniversitesi Tıp Fakültesi’nde Ocak 2012-Ekim 2016 tarihleri arasında Tıbbi Patoloji Anabilim Dalı’nda incelenen 263 apendektomi materyali retrospektif olarak değerlendirildi. Bulgular: Olguların 134 (%51)’ü erkek, 129 (%49)’u kadındı. Yaşları 4 ile 88 arasında değişmekte idi (ortalama=29.4±15.03 yaş). 263 olgunun 167 (%63.4)’sinde akut apandisit, 4 (%1.5)’ünde ise periapandisit bulguları saptandı. Ayrıca, 73 (%27.8) olguda lenfoid hiperplazi, 7 (%2.8) olguda enterobius vermicularis, 5 (%1.9) olguda fibröz obliterasyon, 3 (%1.1) olguda nonnekrotizan granülomatöz inflamasyon, 2 (%0.8) olguda düşük dereceli apendisyal müsinöz neoplazi, 1 (%0.4) olguda lökositoklastik vaskülit ve 1 (%0.4) olguda karsinoid tümör mevcuttu. Sonuç: Akut apandisit ön tanısı ile yapılan apendektomi materyallerinde ek tedavi gerektiren benign/malign tümörler ve paraziter enfeksiyonlar başta olmak üzere çeşitli insidental patolojiler saptanabilmektedir. Bu nedenle, histopatolojik inceleme önemlidir ve dikkatli bir şekilde yapılmalıdır.

Histopathological Diagnoses Detected in Appendectomy Specimens

Objective: The aim of the present study was to evaluate the histopathological diagnoses and their incidences in the appendectomies performed for acute abdomen symptoms in Yozgat region. Material and Method: 263 appendectomy specimens that were evaluated between January 2012 and October 2016 at the Pathology Department of Bozok University School of Medicine, a recently founded university, were investigated retrospectively. Results: There were 134 (51%) males and 129 (49%) females. The age ranged from 4 to 88 years (mean =29.4±15.03 year). Among 263 cases, acute appendicitis was detected in 167 (63.4%) cases and perappendicitis was detected in 4 (1.5%) cases. Additionally, there were 73 (27.8%) cases of lymphoid hyperplasia, 7 (2.8%) cases of enterobius vermicularis, 5 (1.9%) cases of fibrous obliteration, 3 (1.1%) cases of non-necrotizing granuloma-tous inflammation, 2 (0.8%) cases of low-grade appendicial mucinous neoplasm, 1 (0.4%) case of leukocytoclastic vasculitis, and 1 (0.4%) case of carcinoid tumor. Conclusion: A variety of incidental pathologies particularly benign/malignant tumors, and parasitic infections that require additional treatment might be detected in the appendectomy specimens performed for a clinical diagnosis of acute appendicitis. Thus, histopathological examination is crucial and has to be done carefully.

___

  • Yabanoglu H, Caliskan K, Ozgur Aytac H et al. Unusual findings in appendectomy specimens of adults: retrospective analyses of 1466 patients and a review of literature. Iran Red Crescent Med J 2014; 16: 12931.
  • . Flum DR, Koepsell T. The clinical and econo-mic correlates of misdiagnosed appendicitis: na-tionwide analysis. Arch Surg 2002; 137: 799–804.
  • . Türkcü G, Keleş A, Alabalık U ve ark. 1829 apendektomi materyalinin retrospektif olarak değerlendirilmesi. Harran Üniversitesi Tıp Fa-kültesi Dergisi 2015; 12: 193-9.
  • Akbulut S, Tas M, Sogutcu N et al. Unu-sual histopathological findings in appendectomy specimens: a retrospective analysis and literatu-re review. World J Gastroenterol 2011; 17: 1961-70.
  • Duzgun AP, Moran M, Uzun S et al. Unusual findings in appendectomy specimens: evalua-tion of 2458 cases and review of the literature. Indian J Surg 2004; 66: 221-6.
  • Jones AE, Phillips AW, Jarvis JR, Sargen K. The value of routine histopathological examina-tion of appendicectomy specimens. BMC Surg 2007; 7: 17.
  • Tirumani SH, Fraser-Hill M, Auer R et al. Mu-cinous neoplasms of the appendix: a current comprehensive clinicopathologic and imaging review. Cancer Imaging 2013; 13: 14-25.
  • Ahmed MU, Bilal M, Anis K et al. The frequ-ency of enterobius vermicularis infections in patients diagnosed with acute appendicitis in Pakistan. Glob J Health Sci 2015; 7: 196-201.
  • Gatti S, Lopes R, Cevini C et al. Intestinal para-sitic infections in an institution for the mentally retarded. Ann Trop Med Parasitol 2000; 94: 453-60.
  • Arca MJ, Gates RL, Groner JI et al. Clinical manifestations of appendicial pinworms in chil-dren: an institutional experience and a review of the literature. Pediatr Surg Int 2004; 20: 372-5.
  • Sarıçam G, Karaca G, Pehlivanlı F, Yıldırım K. Nadir bir akut apandisit nedeni: enterobius ver-micularis. Van Tıp Dergisi 2014; 21: 114-6.
  • Kurt A, Çalık İ, Ömeroğulları Şener E, Akalp Özmen S, Gelincik İ. Apendektomi materyalle-rinde E. vermicularis. Van Tıp Dergisi 2012; 19: 51-4.
  • Still GF. Oxyuriasis vermicularis in children. Br Med J 1899; 1: 898-900.
  • Surmont I, Liu LX. Enteritis, eosinophilia and enterobius vermicularis. Lancet 1995; 346: 1167.
  • Gupta K, Solanki A, Vasishta RK. Appendiceal neuroma: report of an elusive neuroma. Trop Gastroenterol 2011; 32: 332-3.
  • Akkapulu N, Abdullazade S. Is Enterobius vermicularis infestation associated with acute appendicitis? Eur J Trauma Emerg Surg 2016; 42: 465-70.
  • Sah SP, Bhadani PP. Enterobius vermicularis causing symptoms of appendicitis in Nepal. Trop Doct 2006; 36: 160-2.
  • Ramezani MA, Dehghani MR. Relationship between enterobius vermicularis and the inci-dence of acute appendicitis. Southeast Asian J Trop Med Public Health 2007; 38: 20-3.
  • Wiebe BM. Appendicitis and enterobius ver-micularis. Scand J Gastroenterol 1991; 26: 336-8.
  • Kabukçuoğlu S, Bildirici K, Tel N ve ark. Eski-şehir yüresinde apendektomilerde izlenen pato-lojik bulguların araştırılması. Türkiye Ekopato-loji Dergisi 2001; 7: 25-32.
  • Karaman Ü, Türkmen E, Iraz M, Karataş T, Çolak C. Parasitosis in appendectomy cases. Eur J Gen Med 2010; 7: 317-20.
  • Isik B, Yilmaz M, Karadag N et al. Appendiceal enterobius vermicularis infestation in adults. Int Surg 2007; 92: 221-5.
  • Engin O, Calik S, Calik B, Yildirim M, Coskun G. Parasitic appendicitis from past to present in Turkey. Iran J Parasitol 2010; 5: 57-3.
  • Fleming CA, Kearney DE, Moriarty P, Red-mond HP, Andrews EJ. An evaluation of the re-lationship between Enterobius vermicularis in-festation and acute appendicitis in a paediatric population-a retrospective cohort study. Int J Surg 2015; 18: 154-8.
  • Levens AM, Schurink M, Koetse HA, van Ba-ren R. Infestation with enterobius vermicularis mimicking appendicitis. Ned Tijdschr Geneeskd 2014; 158: A7371.
  • Misdraji J, Graeme-Cook FM. Miscellane-ous conditions of the appendix. Semin Diagn Pathol 2004; 21: 151-63.
  • Şen M, Kılıç MÖ, Yıldırım Ü. Apendisyal nö-roma: akut apandisitin nadir bir nedeni. Yeni Tıp Dergisi 2014; 31: 133-4.
  • Gülden D, Melek Ü, Gülden Ç, Mine T. Nöro-jenik hiperplazi apendiks obliterasyonu nedeni midir? Adnan Menderes Üniversitesi Tıp Fakül-tesi Dergisi 2001; 2: 15-8.