Nimet KABAKUŞ, Abdullah KURT, Çıtak Ayşegül Neşe KURT

Alternanting hemiplegia of childhood associated with bilateral ptosis in a 3-Year-old girl

Çocukluk çağının alternan hemiplejisi; nadir görülen ve hemipleji atakları ile karakterize bir sendromdur. Bu sendrom migren, epilepsy ve ailesel koreatetoz ile ilişkili olabilir. Kranial sinir disfonksiyonu ise oldukça nadirdir. Burada sunulan hastanın, pitoz gelişen iki atağı vardı. Atakların önlenmesi için hastaya Flunarizin tedavisi başlandı ve18 aydır izlenen hastanın herhangibir şikayeti olmadı. Bu olguda olduğu gibi alternan hemiplejinin değişik formları olabilir ve hemipleji-pitoz ile atak gelişebilir.

Anahtar Kelimeler:

Çocuk, okul öncesi, Kraniyal sinirler, Elektroensefalografi, Kadın, Hemipleji

Üç yaşında kız hastada bilateral pitosiz ile ilişkili çocukluk çağı alternan hemiplejisi

Alternating hemiplegia of childhood=Alternating hemiplegia of childhood is a rare and poorly understood clinical syndrome that has hemiplegia as the major feature. The syndrome has been linked to migraine, epilepsy and familial paroxysmal choreoathetosis. Cranial nerve dysfunctions are very rare in Alternating hemiplegia of childhood. We present a child with Alternating hemiplegia of childhood who had two attacks associated with ptosis . Flunarizine therapy was started to prevent a new attack of Alternating hemiplegia of childhood and she has remained free of symptoms with no residual signs during the 18-month follow-up period. As in our case, different forms of Alternating hemiplegia of childhood may be seen and an attack including hemiplegia-ptosis may become an Alternating hemiplegia of childhood episode.

Keywords:

Child, Preschool, Cranial Nerves, Electroencephalography, Female, Hemiplegia,

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1) Verret S, Steele JC. Alternating hemiplegia in childhood: A report of eight with complicated migraine in infancy. Pediatrics 1971; 47: 675-680.
2) Lync JK, Hirtz DG, Nelson KB. Report of the natıonal institute of neurological disorders and stroke workshop on perinatal and childhood stroke. Pedıatrics 2002; 109: 116-123.
3) Aicardi J. Alternating hemiplegia of childhood. Int Pediatr 1987; 2: 115-114.
4) Mikati MA, Kramer U. Alternating hemiplegia of childhood: Clinical manifestatıons and longterm outcome. Pedıatr Neurol 2000; 23: 143-141.
5) Fenichel GM. Clinical Pediatric Neurology (4th). Philadelphia: WB Saunders Company, 2001; 77-89.
6) Johnston MV. Acute Stroke Syndromes. Behrman RE, Kliegman RM, Jensen HB(eds). Nelson Textbook of Pediatrics (17th). Philadelphia: WB Saunders Company, 2004; 2035-2038.
7) Chugani HT, Rho JM. Alternating hemiplegia of childhood insights into its patho physiology. J Child Neurol 1998;13: 39-45.
8) Egan RA. Ocular motor features of alternating hemiplegia of childhood. J Neuroophthalmol 2002; 22: 99-101.
9) Silver K, Andermann F.Alternating hemiplegia of childhood: a study of 10 patients and result of flunarizine treatment. Neurology 1993; 43: 36-44.
10) Haslam RH. Headaches. Behrman RE, Kliegman RM, Jensen HB (eds). Nelson Textbook of Pediatrics (17th). Philadelphia: WB Saunders Company, 2004; 2012-2015.
11) Battistini S, Stenirri S, Piatti M et al. A New CACNA1A in acetazolamide-responsive familial hemiplegic migraine and ataxia. Neurology 1999; 53: 38-43.
12) Horiuchi I, Yoshimura T, Furuya H et al. A case report of alternating abducens hemiplegia with special reference to the supranuclear pathway to the facial nucleus. Rinsho Shinkeigaku 1997; 37: 334-337.
13) Sone K, Oguni H, Katsumori H et al. Successful trial of amantadine hydrochloride for two patients with Alternating hemiplegia of childhood. Neuropediatrics 2000; 31: 307-309.