İSMAİL SARI, TEVFİK DEMİR, Gerçek CAN, Servet AKAR, AHMET MERİH BİRLİK, Fatoş ÖNEN, Mehmet TUNCA, Nurullah AKKOÇ

Ailevi akdeniz ateşi hastalarında vücut kompozisyonunun değerlendirilmesi

Amaç: Ailevi Akdeniz ateşi (AAA) tekrarlayan serozit ataklarıyla karakterize otoinflamatuvar bir romatizma hastalığıdır. Bu çalışmanın amacı AAA hastalarında vücut kompozisyonunun değerlendirilmesidir. Gereç ve Yöntemler: 38 AAA hastası ve 31 sağlıklı kontrol çalışmaya alındı. Hipertansiyon, diyabet ve hiperlipidemisi olan bireyler çalışma dışı bırakıldı. Vücut kompozisyonu değerlendirmesinde antropometrik ölçümler (vücut kitle indeksi; VKİ, bel çevresi, bel-kalça oranı), cilt kıvrım kalınlığı yöntemi ve biyoelektrik impedans analizi (BİA) kullanıldı. Bulgular: Hasta ve kontrollerin yaş, cinsiyet dağılımları, sigara kullanımları, VKİ, bel çevresi, bel-kalça oranları benzer özellikteydi (p>0.05). Her iki gurubun yağ yüzdeleri (gerek Siri gerekse BİA'dan hesaplanan), yağsız vücut kitleleri ve toplam vücut su miktarları arasında farklılık tespit edilemedi. Korelasyon analizinde BİA'dan elde edilen yağ yüzdesi hastalık süresi ve ESH ile anlamlı ilişki göstermekteydi (p

Assessment of body composition in familial mediterranean fever

Objective: Familial Mediterranean fever (FMF) is an autoinflammatory rheumatic disease characterized by the recurrent attacks of serositis. The aim of the present study is to examine the body composition in patients with FMF. Materials and Methods: 38 FMF patients and 31 healthy control subjects included in the study. Patients with hypertension, diabetes and hyperlipidemia were excluded. Body composition was assessed by anthropometrically (body mass index; BMI, waist circumference and waist to hip ratio), skinfold measurements and bioelectric impedance analysis (BIA) methods. Results: Age, sex distribution, smoking status, BMI, waist circumference and waist-to-hip ratios were similar between both FMF and control groups (p>0.05). Fat mass (estimated from both Siri's equation and BIA), fat free mass and total body water amounts were comparable between FMF and control groups (p>0.05). Correlation analysis revealed significant correlations between disease duration, ESR and body fat estimated from BIA (p<0.05). Siri's fat percent was significantly correlated with age disease duration and ESR (p<0.05). Total body water was also correlated with age and ESR (p<0.05). Conclusion: Our study indicated that body composition is not different in FMF patients when compared with healthy subjects.

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1) Sohar E, Gafni J, Pras M, Heller H. Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med. 1967 Aug; 43(2):227-53.
2) Tunca M, Akar S, Onen F, et al. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine. 2005 Jan; 84(1):1-11.
3) Onen F. Familial Mediterranean fever. Rheumatol Int. 2006 Apr;26(6):489-96.
4) Perfetto F, Tarquini R, Simonini G, et al. Circulating leptin levels in juvenile idiopathic arthritis: a marker of nutritional status? Ann Rheum Dis. 2005 Jan; 64(1):149-52.
5) Sari I, Demir T, Kozaci LD, et al. Body composition, insulin, and leptin levels in patients with ankylosing spondylitis. Clin Rheumatol. 2007 Sep; 26(9):1427-32.
6) Souza RB, Borges CT, Takayama L, Aldrighi JM, Pereira RM. Systemic sclerosis and bone loss: the role of the disease and body composition. Scand J Rheumatol. 2006 Sep-Oct; 35(5):384-7.
7) Westhovens R, Nijs J, Taelman V, Dequeker J. Body composition in rheumatoid arthritis. Br J Rheumatol. 1997 Apr; 36(4):444-8.
8) Roubenoff R, Rall LC. Humoral mediation of changing body composition during aging and chronic inflammation. Nutr Rev. 1993 Jan; 51(1):1-11.
9) Livneh A, Langevitz P, Zemer D, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997 Oct; 40(10):1879-85.
10) Durnin JV, Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr. 1974 Jul; 32(1):77-97.
11) Siri NE. Advances in biological and medical physics. Lawrence JH, Tobias CA, editors. London and New York: Academic Press; 1956.
12) Ellis KJ. Human body composition: in vivo methods. Physiol Rev. 2000 Apr;80(2):649-80.
13) Fogelholm M, van Marken Lichtenbelt W. Comparison of body composition methods: a literature analysis. Eur J Clin Nutr. 1997 Aug; 51(8):495-503.
14) Sheng HP, Huggins RA. A review of body composition studies with emphasis on total body water and fat. Am J Clin Nutr. 1979 Mar; 32(3):630-47.
15) Lofthouse CM, Azad F, Baildam EM, Akobeng AK. Measuring the nutritional status of children with juvenile idiopathic arthritis using the bioelectrical impedance method. Rheumatology (Oxford). 2002 Oct; 41(10):1172-7.
16) Rall LC, Rosen CJ, Dolnikowski G, et al. Protein metabolism in rheumatoid arthritis and aging. Effects of muscle strength training and tumor necrosis factor alpha. Arthritis Rheum. 1996 Jul; 39(7):1115-24.
17) Roubenoff R, Roubenoff RA, Ward LM, et al. Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor. The Journal of rheumatology. 1992 Oct;19(10):1505-10.
18) Gallagher D, Song MY. Evaluation of body composition: practical guidelines. Prim Care. 2003 Jun; 30(2):249-65.
19) Vasudev S, Mohan A, Mohan D, et al. Validation of body fat measurement by skinfolds and two bioelectric impedance methods with DEXA--the Chennai Urban Rural Epidemiology Study [CURES-3]. The Journal of the Association of Physicians of India. 2004 Nov; 52:877-81.
20) Lachmann HJ, Sengul B, Yavuzsen TU, et al. Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology (Oxford). 2006 Feb 9; 45(6):746-50.
21) Ozcakar ZB, Yalcinkaya F, Yuksel S, et al. Possible effect of subclinical inflammation on daily life in familial Mediterranean fever. Clin Rheumatol. 2006 Mar; 25(2):149-52.