Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü

Nörogenez, nöral kök hücrelerin (NKH) bölünme, göç etme ve fark-lılaşma süreçlerinin bütününü oluşturmaktadır. Lateral ventrikülün subventriküler bölgesi (SVZ) ve hipokampus dentat girus (DG)’daki subgranüler bölge (SGZ) olmak üzere iki farklı nişte gerçekleşmek-tedir. Nörotrofik faktörler, NKH ve nöral progenitor hücrelerin mig-rasyon, proliferasyon ve farklılaşmasında rol oynar. Ayrıca, NKH’le-rin hasarlı dokuda, nöral hücrelerin yeniden yapılanması, nöral plastisite ve anjiogenezi düzenleyici etkileri olduğu gösterilmiştir. Yetişkin nörogenezinde ise nörotrofik faktör kombinasyonlarının serebrovasküler, nörodejeneratif, onkolojik hastalıklar ve travma sonrası oluşan inflamatuvar hasar tedavisinde önemli rolü olduğu bilinmektedir. Bu derlemede, nörotrofik faktörlerin NKH’ler üzerin-deki modüle edici etkisi ve potansiyel terapötik uygulamalarında preklinik ve klinik çalışmaları içeren güncel literatürler biraraya ge-tirilmiştir. Bu alanda çalışma yapan araştırmacı ve hekimlere fayda sağlayacak güncel bilgiler içermektedir.

The Role of Growth Factors in Adult Neurogenesis and Neurodegenerative Diseases

Neurogenesis is the combined processes of division, migration and differentiation of neural stem cells (NSCs). The two different loca-tions: the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) in the hippocampus dentate gyrus (DG), provide a niche environment for neurogenesis. Neurotrophic fac-tors have roles on migration, proliferation and differentiation of NSC and neural progenitor cells. Studies have shown that NSCs have regulatory effects on neural cell rearrangement, neural plas-ticity and angiogenesis in damaged tissue. In adult neurogenesis, combinations of neurotrophic factors play an important role in the treatment of cerebrovascular, neurodegenerative, oncological diseases and post-traumatic inflammatory damage. In this review, current literature including pre-clinical and clinical studies for the modulating effect of neurotrophic factors on NSCs and their po-tential therapeutic treatment applications are brought together. It contains up-to-date information that would be beneficial for re-searchers and physicians working in this field.

Kaynakça

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Kaynak Göster

Bibtex @derleme { experimed831169, journal = {Experimed}, issn = {}, eissn = {2667-5846}, address = {}, publisher = {İstanbul Üniversitesi}, year = {2021}, volume = {11}, pages = {57 - 66}, doi = {10.26650/experimed.2021.831169}, title = {Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü}, key = {cite}, author = {Toprak, Fatih and Toprak, Selin and Sozer Tokdemir, Selcuk} }
APA Toprak, F , Toprak, S , Sozer Tokdemir, S . (2021). Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü . Experimed , 11 (1) , 57-66 . DOI: 10.26650/experimed.2021.831169
MLA Toprak, F , Toprak, S , Sozer Tokdemir, S . "Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü" . Experimed 11 (2021 ): 57-66 <https://dergipark.org.tr/tr/pub/experimed/issue/62231/831169>
Chicago Toprak, F , Toprak, S , Sozer Tokdemir, S . "Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü". Experimed 11 (2021 ): 57-66
RIS TY - JOUR T1 - Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü AU - Fatih Toprak , Selin Toprak , Selcuk Sozer Tokdemir Y1 - 2021 PY - 2021 N1 - doi: 10.26650/experimed.2021.831169 DO - 10.26650/experimed.2021.831169 T2 - Experimed JF - Journal JO - JOR SP - 57 EP - 66 VL - 11 IS - 1 SN - -2667-5846 M3 - doi: 10.26650/experimed.2021.831169 UR - https://doi.org/10.26650/experimed.2021.831169 Y2 - 2021 ER -
EndNote %0 Experimed Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü %A Fatih Toprak , Selin Toprak , Selcuk Sozer Tokdemir %T Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü %D 2021 %J Experimed %P -2667-5846 %V 11 %N 1 %R doi: 10.26650/experimed.2021.831169 %U 10.26650/experimed.2021.831169
ISNAD Toprak, Fatih , Toprak, Selin , Sozer Tokdemir, Selcuk . "Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü". Experimed 11 / 1 (Mayıs 2021): 57-66 . https://doi.org/10.26650/experimed.2021.831169
AMA Toprak F , Toprak S , Sozer Tokdemir S . Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. Experimed. 2021; 11(1): 57-66.
Vancouver Toprak F , Toprak S , Sozer Tokdemir S . Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. Experimed. 2021; 11(1): 57-66.
IEEE F. Toprak , S. Toprak ve S. Sozer Tokdemir , "Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü", Experimed, c. 11, sayı. 1, ss. 57-66, May. 2021, doi:10.26650/experimed.2021.831169

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