Giant Cell Angiofibroma: A Rare Tumour in the Oral Cavity

Giant Cell Angiofibroma: A Rare Tumour in the Oral Cavity

Giant cell angiofibroma (GCA) was first described as a distinctive orbital soft-tissue tumour. It is now recognised that this rare tumour can present in other anatomical regions including the oral cavity. Here, we report a case of a 26-year-old male with a primary complaint of a painless solitary swelling on the right buccal mucosa. The lesion was surgically excised and a diagnosis of GCA was made based on light microscopy and immunohistochemical (IHC) studies. At present, local excision with long-term follow-up seems to be the most appropriate management modality. To the best of our knowledge, only four cases of GCA arising in the oral cavity were reported in the literature.

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  • 1.Dei TA, Seregard S, Calonje E, Chan JK, Fletcher CD. Giant cell angiofibroma. A distinctive orbital tumor in adults. Am J SurgPathol 1995;19:1286-93.
  • 2. Kintarak S, Natiella J, Aguirre A, Brooks J. Giant cell angiofibroma of the buccal mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol. Endod. 1999 Dec;88(6):707-13.
  • 3. Rousseau A, Perez-Ordonez B, Jordan RC. Giant cell angiofibroma of the oral cavity: report of a new location for a rare tumor. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 1999 Nov;88(5):581-5.
  • 4. de Andrade CR, Lopes MA, de Almeida OP, León JE, Mistro F, Kignel S. Giant cell angiofibroma of the oral cavity: a case report and review of the literature. Med Oral Patol Oral Cir Bucal. 2008; 13:E540–E543.
  • 5. Ajura Abdul Jalil, Lau Shin Hin. Oral giant cell angiofibroma: A case report. Oral Surg Oral Med Oral Pathol Oral Radiol.2015 March: E158.
  • 6. Husek K, Vesel K. Extraorbital giant cell angiofibroma. CeskPatol. 2002 Jul;38(3):117-20. 6. Qian YW, Malliah R, Lee HJ, Das K,Mirani N, Hameed M. A t(12;17) in an extraorbital giant cell angiofibroma. Cancer Genet Cytogenet. 2006 Mar;165(2):157-60.
  • 7. Thomas R, Banerjee SS, Eyden BP, Shanks JH, Bisset DL, Hunt R, et al. A study of four cases of extra-orbital giant cell angiofibromawith documentation of some unusual features. Histopathology. 2001 Oct;39(4):390-6.
  • 8. .Fletcher CD. Giant cell fibroblastoma of soft tissue: a clinicopathological and immunohistochemical study. Histopathology 1988;13:499-508.
  • 9. Dalton WT, Zolliker AS, McCaughey WTE, Jacques J, Kanerstein M. Localized primary tumors of the pleura. Cancer 1979;44:1465-75.
  • 10. Goodlad JR, Fletcher CD. Solitary fibrous tumour arising at unusual sites: analysis of a series. Histopathology 1991;19:515- 22.