Kistik Ekinokokkozisli Sığır Akciğerlerinde Hücre Adezyon Moleküllerinin Araştırılması

Kistik ekinokokkozis, dünya çapında Echinococcus granulosus’un neden olduğu geniş dağılımı olan zoonotik 

The Investigation of Cell Adhesion Molecules in the Lung Tissues of Cattle with Cystic Echinococcosis

Cystic echinococcosis is a zoonotic disease with worldwide distribution caused by Echinococcus granulosus, represents a substantial global health problem. Hydatid cyst (Echinococcus) has a remarkable negative effect on the health of people and the economic development of the country. The objective of this study was to investigate the CD68, nicotinamide nucleotide adenylyltransferase 3 (NMNAT 3), Neuregulin 1 (NRG1) and Neuregulin 2 (NRG2) expres-sions in bovine lungs infected with E. granulosus and to identify whether they have any correlation with pulmonary pathology. For this purpose, 30 bovine lung tissues were used between January 2016 and December 2016 collected in Kırıkkale  slaughterhouse.  In  histopathologic  examinations,  proliferation  of  fibrous  connective  tissue  and  infiltration of mononuclear cells were detected in the lung tissues of the bovine. Most of the cysts were seen to be quite thick capsule. There was also a cellular line rich in abundant fibroblasts and mononuclear cells. The cyst wall was found to be an eosinophilic laminar structure. There was infiltration with lymphocytes and macrophages, especially eosinophils and giant cells. Immunohistochemically, CD68 positivity was seen around the bronchi, bronchioles and cystic matter. However; NMNAT 3, NRG1 and NRG2 showed no positive reactions in macrophages, bronchi, bronchioles and alveo-lar epithelium. These results indicate that NMNAT 3, NRG1 and NRG2 pathways were not used in pulmonary pathol-ogy. Therefore, it is the most important result of the study that the adhesion molecules in pulmonary pathology are not originating from NMNAT 3, NRG1 and NRG2.

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Kaynak Göster

APA Yavuz, O , Dinçel, G , Gökpınar, S , Haydardedeoğlu, A . (2019). The Investigation of Cell Adhesion Molecules in the Lung Tissues of Cattle with Cystic Echinococcosis . Etlik Veteriner Mikrobiyoloji Dergisi , 30 (1) , 14-19 . DOI: 10.35864/evmd.586538

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