Yavuz ULUSOY, Burhan TOPRAK, Meltem UZUNHİSARCIKLI, Ayşe ÖĞÜTÇÜ

Diazinonun Sıçan Hepatositleri Üzerine Etkisinin Elektron Mikroskobu ile İncelenmesi

Diazinon zirai mücadelede yaygın olarak kullanılır ve hem insanlar hem de hayvanlar tarafından sindirim, solunum ve deri yoluyla absorbe olmaktadır. Bu çalışmada 15mg/kg/gün diazinon mısır yağı içinde erkek Wistar ratlara 5 hafta boyunca oral intibasyon yolu ile verilmiştir. Elektron mikroskobuyla yapılan inceleme sonucunda 1. hafta sonunda hepatositlerde patolojik bir durum gözlenmezken, 2. hafta sonunda mitokondrilerde hafif şişme, 3. hafta sonunda mitokondrilerde aşırı şişme, 4.hafta sonunda hepatositlerde şişme, 5. hafta sonunda hepatositlerde piknotik çekirdek, sitoplazmada vakuolizasyon ve mitokondrilerde şişme ve vakuolizasyon meydana gelmiştir.

Anahtar Kelimeler:

Diazinon, Pestisit, Karaciğer, Elektron Mikroskobu, Etlik Veteriner Mikrobiyoloji Dergisi, 2004, Yavuz ULUSOY, Burhan TOPRAK, Meltem UZUNHİSARCIKLI, Ayşe ÖĞÜTÇÜ

Electron Microscopic İnvestigation of Effects of Diazinon on Rat's Hepatacytes

Diazinon is widely used in agricultural control and it is absorbed by both human and animals through ingestion, inhalation and percutaneously. In this study diazinon was given to male Wistar rats by oral intubatian 15mg/kg/per day in corn oil for 5 weeks. The result of investigations with electron microscopy: at the end of l week no pathofogical findings was observed, at the end of 2 week weak swelling of mitochondria, at the end of 3rd week extreme swelling ofmitochondria, at the end of 4th week swelling of hepatocyle, at the end of 5'th week picnotic nucfeus in hepatocytes. vacuolization of cytoplasm and swelling and vacuolization of mitochondria were occurred.

Keywords:

Diazinon, pestisicides, liver, electron microscopy,

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