Hemochromatosis Presenting with Diabetic Ketoacidosis: A Rare Case Report

Hemochromatosis, although increasingly recognized by clinicians, is still underdiagnosed because it is often considered a rare disorder. The fully established disease consists of cirrhosis, diabetes, and skin pigmentation (bronze diabetes). Diabetes can occur as a result of direct islet cell damage due to iron infiltration. Presentation with diabetic ketoacidosis is rare, and only few cases have been reported. This case report is of a patient with hemochromatosis presenting with diabetic ketoacidosis.

Kaynakça

Chung RT, Misdraji J, Sahani DV. Case records of the Massachusetts General Hospital. Case 33-2006. A 43-year-old man with diabetes, hypogonadism, cirrhosis, arthralgias, and fatigue. N Engl J Med 2006; 355(17): 1812-9. [CrossRef]

Phatak PD, Bonkovsky HL, Kowdley KV. Hereditary hemochroma- tosis: time for targeted screening. Ann Intern Med 2008; 149(4): 270-2. [CrossRef]

O'Sullivan EP, McDermott JH, Murphy MS, Sen S, Walsh CH. Declin- ing prevalence of diabetes mellitus in hereditary haemochromatosis- -the result of earlier diagnosis. Diabetes Res Clin Pract 2008; 81(3): 316-20. [CrossRef]

Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996; 13(4): 399-408. [CrossRef]

Tavill AS. American Association for the Study of Liver Diseases; American College of Gastroenterology; American Gastroenterological Association. Diagnosis and management of hemochromatosis. Hepa- tology 2001; 33(5): 1321-8. [CrossRef]

Adams PC, Deugnier Y, Moirand R, Brissot P. The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis. Hepatology 1997; 25(1): 162-6. [CrossRef]

Crawford DH, Jazwinska EC, Cullen LM, Powell LW. Expression of HLA-linked hemochromatosis in subjects homozygous or hetero- zygous for the C282Y mutation. Gastroenterology 1998; 114(5): 1003-8. [CrossRef]

Yaouanq JM. Diabetes and haemochromatosis: current concepts, management and prevention. Diabetes Metab 1995; 21(5): 319-29.

Vazirani S, Kashefi MJ. Diabetic Ketoacidosis as a Presentation of Hemochromatosis. Federal Practitioner 2010: 23-5.

Pasternak DP. Hemochromatosis presenting as diabetic ketoacidosis with extreme hyperglycemia. West J Med 1974; 120(3): 244-6.

Buretic-Tomljanovic A, Vlastelic I, Radojcic Badovinac A, Starcevic- Cizmarevic N, Nadalin S, Ristic S. The impact of hemochromatosis mutations and transferrin genotype on gonadotropin serum levels in infertile men. Fertil Steril 2009, 91(5): 1793-800. [CrossRef]

McDonnell SM, Preston BL, Jewell SA, Barton JC, Edwards CQ, Adams PC, et al. A survey of 2,851 patients with hemochromatosis: Symptoms and response to treatment. Am J Med 1999; 106(6): 619-24. [CrossRef]

Kaynak Göster

678 371

Arşiv
Sayıdaki Diğer Makaleler

A case of Langerhans Cell Histiocytosis with Multisystemic Involvement in an Adult Patient

Beril GÜLÜŞ DEMİREL, Nilgün Solak TEKİN, FİGEN BARUT, Müzeyyen ASLANER, RAFET KOCA, Duygu GENCER

Prevalence of Modified Lothrop (Draf-III) Frontal Sinus Surgery Indications in Iran and their Association with Symptom Release

Peyman BOROOMAND, Masoumeh SAEEDİ, Hamidreza KARİMİ-SARİ, Seyed Hadi Samimi ARDESTANİ, Mojtaba Mohammadi ARDEHALİ, Mahdi RAMEZANİ-BİNABAJ

A Rare and Unexpected Cause of Pulmonary Hypertension: Pulmonary Capillary Hemangiomatosis

GONCA KOÇ, Selim DOĞANAY, NURİ TUTAR, OLGUN KONTAŞ, İNCİ GÜLMEZ, Mehmet Sait DOĞAN, SÜREYYA BURCU GÖRKEM, Abdulhakim COŞKUN

Hemochromatosis Presenting with Diabetic Ketoacidosis: A Rare Case Report

Deepak JAIN, VK KATYAL, Ashima MİTTAL, Promil JAIN

Humans as a Source of Colistin Resistance: In Silico Analysis of Public Metagenomes for the mcr-1 Gene in the Gut Microbiome

AYCAN GÜNDOĞDU, Özkan Ufuk NALBANTOĞLU

Pericardioperitoneal Fenestration for Chylopericardium

AYDIN TUNÇAY, Yiğit AKÇALI, Faruk SERHATLIOĞLU, Rıfat ÖZMEN, Özer GAZİOĞLU

Following Autopsy Results in Patients who died of Unintentional Trauma

Mahboub POURAGHAEİ, Bahram SAMADİ RAD, Shahryar Hashem ZADEH, Payman MOHARRAMZADEH, Samad Shams VAHDATI, Zahed MAGHSUDİ

Discovery of a Small Primary Tumor on the Appendix Tip in a Patient with Liver Neuroendocrine Metastases via Ga-68 DOTA-TATE PET/CT Images

ÜMMÜHAN ABDÜLREZZAK, Mustafa KULA, AHMET TUTUŞ