Sol-Jel Yöntemi ile Sentezlenen Antibakteriyel Kalsiyum Fosfat/Kitosan/Çinko Kaplamanın İncelenmesi

Ortopedik veya dental implant uygulamalarında yaygın olarak kullanılan kalsiyum fosfat kaplamalar mükemmel biyoaktivite ve osteokonduktiviteye sahip olsalar da enfeksiyon riski taşımaktadırlar. Bu çalışmada, Titanyumun yüzeyinde hem biyoaktif hem de antibakteriyel özellik sağlayan kalsiyum fosfat/kitosan/çinko içerikli biyokompozit kaplama sol-jel yöntemi ile elde edilmiştir. Kaplamanın karakterizasyon çalışmaları X-ışını kırınımı (XRD), Taramalı Elektron Mikroskobu (SEM), Enerji Dağılım Spektroskopi (EDS) ve Fourier Dönüşümlü Kızılötesi Spektroskopi (FTIR) analizleri ile gerçekleştirilmiştir. Kalsiyum fosfat içerikli kaplamaya, biyouyumlu kitosan ve çinko ilavesi antibakteriyel özellik kazandırmıştır. Elde edilen sonuçlara göre postoperatif cerrahi enfeksiyonlarının önlenmesi için antibiyotik kullanmadan geliştirilen bu kaplama umut vericidir.

Anahtar Kelimeler:

Antibakteriyel kaplama, sol-jel, implant

Investigation of Antibacterial Calcium Phosphate / Chitosan / Zinc Coating Synthesized by Sol-Gel Method

Although calcium phosphate coatings, which are widely used in orthopedic or dental implant applications, have excellent bioactivity and osteoconductivity, they carry a risk of infection. In this study, calcium phosphate / chitosan / zinc containing biocomposite coating, which provides both bioactive and antibacterial properties on the surface of Titanium, was obtained by sol-gel method. The characterization studies of the coating were carried out by X-ray diffraction (XRD), Scanning Electron Microscope (SEM), Energy Dispersion Spectroscopy (EDS) and Fourier Transform Infrared Spectroscopy (FTIR) analyzes. The addition of biocompatible chitosan and zinc to the calcium phosphate-containing coating has provided antibacterial properties. According to the results, this coating, which was developed without using antibiotics to prevent postoperative surgical infections, is promising.

Keywords:

Antibacterial coating, sol-gel, implant,

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