Donepezil HCl Salımı İçin Düşük Konsantrasyonlarda Titanyum Dioksit Nanopartikülü İçeren Fotopolimerize Edilebilir HEMA/PEG-DA Tabanlı Hidrojellerin Hazırlanması

2-hidroksil etil metakrilat/poli (etilen glikol) diakrilat (HEMA / PEG-DA) tabanlı hidrojeller, biyobozunur olma ve sürekli salım gibi çekici özellikleri nedeniyle ilgi çekici ilaç taşıyıcılarıdır. Bu çalışmanın kapsamı, düşük konsantrasyonlarda titanyum dioksit (TiO2) nanopartikülü içeren HEMA / PEG-DA tabanlı hidrojellerin şişme ve salınım davranışlarını araştırmaktır. Hidrojeller, fotopolimerizasyon ile başarılı bir şekilde sentezlenmiştir. Fotopolimerizasyon için 2,2-dimetoksi-2-fenil-asetofenon (Irgacure 651), 1-hidroksisikloheksil fenil keton (Irgacure 184) ve 2-hidroksi-4'-(2-Hidroksietoksi) -2 metilpropiofenon (Irgacure 2959) seçilmiştir. Fourier Dönüşümlü Kızılötesi Spektroskopisi (FT-IR), hidrojellerin fonksiyonel grubunu doğrulamak için kullanılmıştır. Digital mikroskop ve taramalı elektron mikroskopu hidrojellerin karakterizasyonu için kulanılmıştır. Bu çalışma, hidrojel içeriğinin, fotobaşlatıcıların türünün ve pH'ın, Donepezil Hidroklorür’ün (Alzheimer hastalığı için ilaç etken maddesi (Active Pharmaceutical Ingredient (API)) şişme ve salım davranışlarının üzerinde önemli bir etkiye sahip olduğunu ortaya koymuştur.

Anahtar Kelimeler:

titanyum dioksit nanopartikülü, , Donepezil HCl, Şişme, Salım, HEMA/PEG-DA tabanlı hidrojeller,

Preparation of Photopolymerizable HEMA/PEG-DA Based Hydrogels Filled with Low Concentrations of Nanoparticle Titanium Dioxide for Release Of Donepezil HCl

: 2-hydroxyl ethyl methacrylate/poly(ethylene glycol) diacrylate (HEMA/PEG-DA) based hydrogels are attractive drug carriers due to their appealing properties such as biodegradability and sustained release. The scope of this study was to investigate the swelling and release behaviors of HEMA/PEG-DA-based hydrogels filled with low concentrations of nanoparticle titanium dioxide (TiO2). Hydrogels have been synthesized successfully by photopolymerization. 2,2-Dimethoxy-2-Phenyl-Acetophenone (Irgacure 651), 1-Hydroxycyclohexyl Phenyl Ketone (Irgacure 184) and 2-Hydroxy-4'-(2-Hydroxyethoxy)-2 Methylpropiophenone (Irgacure 2959) were selected for photopolymerization. Fourier Transform Infrared Spectroscopy (FT-IR) had been used in confirming the functional group of hydrogels. A digital microscope and Scanning Electron Microscope (SEM) were used for characterizing synthesized hydrogels. This study revealed that the content of hydrogels, the kind of photo-initiators and pH have a significant effect on the swelling and releasing of Donepezil Hydrochloride (active pharmaceutical ingredient (API) for Alzheimer disease) behaviours.

Keywords:

HEMA/PEG-DA based hydrogels, Nanaoparticle titanium dioxide, Donepezil HCl, , Swelling, Releasing,

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