Yegane Selma TOSUN, Murat YÜCETÜRK, Sevim BENZERGİL

The immunization of babies born of HBsAg positive pregnant women

Hepatitis B virüs (HBV) ile infekte gebelerin doğum sırasında vertikal yolla yenidoğan bebeklerini infekte etme olasılıkları vardır. Özellikle annesinde HBsAg ve HBeAg pozitif olan bebekler HBV nin peripartum bulaşması açısından risk altındadır. Bu çalışmada HBsAg taşıyıcı gebeleri saptamak amacıyla EIA yöntemiyle HBV ile karşılaşma durumlarını belirlemek amacıyla tetkik edilmiş ve yaşları 18-40 arası 540 gebede HBsAg, total antiHBc ve antiHBs bakılmıştır. Taşıyıcı annelerden doğan tüm bebeklere doğum sonrası ilk 6 saat içinde aktif (HBV aşısı) ve pasif (hepatit B hiperimmunglobulin) immünizasyon uygulanmış aşı şeması 0-1-2-12. aylar olarak sürdürülmüştür. Bu bebeklerin ve ayrıca taşıyıcı annelerin izlemleri 4 yıldır sürdürülmektedir ve bebeklerde immunizasyonu takiben oluşan koruyucu antiHBs düzeyleri halen devam etmektedir. Bu sonuçlar, tüm gebelerin gebelik sırasında HBsAg yönünden tetkik edilmesinin ve HBV'den korunmak için taşıyıcı annelerin bebeklerinin en kısa zamanda immünizasyonunun gerekliliğini göstermektedir.

Anahtar Kelimeler:

Taşıyıcılık, Hepatit B yüzey antijenleri, Gebelik, Aşılama

HBsAg pozitif gebelerden doğan bebeklerin immünizasyonu

Pregnant women infected with hepatitis B virus (HBV) pose a risk for infecting their newborn infants by vertical transmission. Especially infants of mothers positive for HBsAg and HBeAg are at risk for peripartal transmission of hepatitis B infection. In this study, HBsAg investigation was carried out by using EIA method in order to determine the HBsAg carrier pregnant women. We studied 540 women aged 18-40 years for determining the HBV status and their sera were tested for HBsAg, antiHBc IgG and antiHBs. All newborns who were born of HBsAg carrier mothers were given active (HBV vaccine) and passive immunization (hepatitis B hyperimmunoglobuline) postpartum within 6 hours and vaccination schedule was continued as 0-1-2-12 months of life. The monitoring of those babies and the other pregnants has still been going on since four years and the infants are still kept protective anti HBs level. These results suggest that all pregnants should be tested for HBsAg during pregnancy and HBV carrier mothers newborns should be immediately immunized for preventing HBV

Keywords:

Carrier State, Hepatitis B Surface Antigens, Pregnancy, Vaccination,

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