Sirolimus salınımlı stent implantasyonundan çok uzun süre sonra gelişen koroner arter anevrizması
İlaç salınımlı stentler (İSS), yakın dönemde cerrahi girişim planlı ya da ikili antiplatelet tedaviyi uzun dönem kullanamayacak olan ve kanama riski yüksek hastalar haricinde çıplak stentlere üstündür. İSS kullanımı, düşük restenoz oranları nedeniyle giderek artmaktadır. Ancak İSS kullanımında gecikmiş endotelizasyon nedeniyle özellikle erken dönemde koroner arter anevrizması (KAA) gelişimine karşı dikkatli olunması gerektiği bildirilmektedir. Bu yazıda İSS uygulanmasından çok uzun süre sonra KAA gelişen bir olgu sunulmuştur
Very late development of coronary artery aneurysm with sirolimus eluting stent
Drug eluting stents (DES) are superior to bare metal stents except in patients scheduled surgery recently, high risk of bleeding and in patients cannot use long-term dual antiplatelet therapy. DESs are being used increasingly due to low rate of restenosis. However, especially in the early stage, it is reported that caution against the development of coronary artery aneurysm (CAA) is required because of delayed endothelialization with DES. In this case report, we present a case with very late development of CAA after DES implantation
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- Stettler C, Wandel S, Allemann S, et al. Outcomes associated with drug eluting stents: A collaborative network metaanalysis. Lancet 2007;370(9591):937-48.
- Virmani R, Guagliumi G, Farb A, et al. Localized hypersensitivity and late coronary trombosis secondary to a sirolimus-eluting stent: Should we be cautious? Circulation 2004;109(6):701-5.
- Joner M, Finn AV, Farb A, et al. Pathology of drug eluting stents in humans: Delayed healing and late trombotic risk. J Am Coll Cardiol 2006; 48(1): 193-202.
- 4.Gupta RK, Sapra R, Kaul U. Early aneurysm formation after drug-eluting stent implantation: An unusual life-threatening complication.J Invasive Cardiol2006;18(4):E140-2.
- 5.Özden K, Şengül C, Fotbolcu H, Dindar İ. A late coronary aneurysm after sirolimus stent implantation which was treated with coronary graft stent. Türk Kardiyoloji Dern Arş 2012;40(5):440-3
- .6.Tanabe K, Serruys PW, Değertekin M, et al. Incomplete stent apposition after implantation of paclitaxel-eluting stents or bare metal stents: Insight from the randomized TAXUS II trial. Circulation 2005;111(7):900-5.
- 7.Hong MK, Mintz GS, Lee CW, et al. Late stent malapposition after drug-eluting stent implantation: An intravascular ultrasound analysis with long-term follow up.Circulation 2006;113(3):414-9
- 8.Mukku VK, Cai Q, Barbagelata A, Conti VR, Fujise K. Very latedevelopment of coronaryartery aneurysmwith total occlusion following sirolimus-eluting stent implantation.Int J Angiol2012;21(4):229-32.
- 9.Aoki J, Kirtane A, Leon MB, Dangas G. Coronary artery aneurysms after drug-eluting stent implantation. JACC Cardiovasc Interv 2008;1(1):14-21