Sekiz haftalık iki farklı yürüme programının orta yaşlı kadınlarda aerobik kapasite, kan lipid profili ve homosistein düzeyleri üzerine etkileri

Çalışmamızın amacı sekiz hafta süreli, iki farklı yürüyüş programının orta yaşlı kadınlardaki aerobik kapasite (VO2max), kan lipid profili, homosistein, vitamin B12, ve folik asit düzeyleri üzerine etkisini incelemektir. Bu amaçla çalışmaya 30-50 yaşları arasında 30 sağlıklı bayan dahil edildi ve bunlar; hızlı tempo yürüyüş grubu (HTYG; n= 10), orta tempo yürüyüş grubu (OTYG; n=10) ve kontrol grubu (KG; n= 10) olarak 3 gruba ayrıldı. Egzersiz grupları, haftada beş gün, günde 30 dakikadan başlayarak 48 dakikaya kadar sabit bir şekilde artan sürelerde yürüdüler. HTYG kalp atım sayısı yedeğinin yaklaşık ~%71 şiddetinde ve ~6.85$\pm$0.32 km/s hızla; OTYG ise kalp atım sayısı yedeğinin ~%51 şiddetinde ve ~5.20±0.14km/s hızla yürüdü. Antrenman periyodundan önce ve sonra maksimal oksijen tüketimi (VÖ2max), kan basınçları, total kolesterol (TK), trigliserid (TG), yüksek yoğunluklu lipoprotein kolesterol (HDL-K), düşük yoğunluklu lipoprotein kolesterol (LDL-K), homosistein, Vitamin B12, folik asit düzeyleri ölçüldü. VO2max HTYG'de daha belirgin olmak üzere her iki egzersiz grubunda artarken (p

The effect of two different eight-week walking programs on aerobic capacity, blood lipid profile, and homocysteine levels in middle-aged women

The aim of the study was to investigate the effect of two different eight-week walking programs on aerobic capacity (VO2maxA blood lipid profile, homocysteine (Hey),.vitamin B12, and folic acid levels in the middle-aged women. For this purpose, 30 healthy women (aged between 30-50 years) enrolled in the study and were divided into three groups as: brisk walking group (BWG; n=10), moderate tempo walking group (MTWG; n=10) and control group (CG; n=10). Exercise groups walked for eight weeks, five days per week from 30min per day steadily increasing up to 48min. BWG and MTWG walked at -71% heart rate reserve (HRR), and at ~51%HRR; at the speed of ~6.85±0.32km/h and ~5.20$\pm$0.14km/h, respectively. Maximal oxygen consumption (VO2max), blood pressures, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), Hey, vitamin B12, folic acid levels were measured before and after the study. Favoring BWG, VO2max increased (p<0.01); Systolic blood pressure (SBP) decreased (p<0.05) in both exercise groups. Despite no change in TC, HDL-C increased (p<0.01), LDL-C decreased (p<0.05) in exercise groups. While Hey increased (p<0.05) in exercise groups, vitamin B12 levels decreased in BWG (p<0.05) and tended to decrease in MTWG (p=0.Q59). Folic acid levels of BWG reduced (p<0.05). In conclusion, we determined that walking with high tempo increased aerobic capacity more dominantly, but that both type of walking resulted in similar positive effects on blood lipid profiles and SBP. The increasing effect of both walking types on Hey is thought to be related to the decrease in vitamin B12 and folic acid levels.

___

  • 1. Morris R, Digenio A, Padayachee GN, Kinnear B. The effect of a 6-month cardiac rehabilitation program on serum lipoproteins and apoproteins A1 and B and lipoprotein a. S Afr Med J 1993; 83: 315-8.
  • 2. Clarke R, Stansbie D. Assessment of homocysteine as a cardiovascular risk factor in clinical practice. Ann Clin Biochem 2001; 38:624-632.
  • 3. de Bree A, Verschuren WM, Blom HJ, Kromhout D. Lifestyle factors and plasma homocysteine concentrations in a general population sample. Am J Epidemil 2001; 154:150-154.
  • 4. Medina M, Urdiales JL, Amores-Sanchez MI. Roles of homocysteine in cell metabolism: Old and new functions. Eur J Biochem 2001; 268:3871-3882.
  • 5. Wright M, Francis K, Cornwell P. Effect of acute exercise on plasma homocysteine. J Sports Med Phys Fitness 1998; 38:262-265.
  • 6. De Cree C, Malinow MR, van Kranenburg GP, et al. Influence of exercise and menstrual cycle phase on plasma homocysteine levels in young women –a prospective study. Scan J Med Sci Sports 1999; 9:272-278.
  • 7. Bailey DM, Davies B, Baker J. Training in hypoxia: modulation of metabolic and cardiovascular risk factors in men. Med Sci Sports Exerc 2000; 32:1058-1066.
  • 8. Randeva HS, Lewandowski KC, Drzewoski J, et al. Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome. J Clin Endocrinol Metab 2002; 87:4496-4501.
  • 9. König D, Bisse E, Deibert P, et al. Influence of training volume and acute physical exercise on the homocysteine levels in endurance-trained men: interactions with plasma folate and vitamin B12. Ann Nutr Mtab 2003; 47:114-118.
  • 10. Williams MH. Vitamin supplementation and athletic performance. Int J Vitam Nutr Res Suppl 1989; 30:163-191.
  • 11. Kok FJ. Folic acid, vitamins B6 and B12: Relation to homocysteine and cardiovascular disease, Walter P, Hornig D, Moser UK,eds. Functions of Vitamins Beyond Recommended Daily Allowance. Bibl Nutr Dieta. Basel, Karger, 2001: 55, 189-191.
  • 12. Rasmussen LB, Ovesen L, Bulow I, et al. Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women. Am J Clin Nutr 2000; 72:1156-1163.
  • 13. Kato I, Dnistrian AM, Schwartz M, et al. Epidemiologic correlates of serum folate and homocysteine levels among users and nonusers of vitamin supplement. Int J Vitm Nutr Res 1999; 69:322-329.
  • 14. Duncan JJ, Gordon NF, Scott CB. Women walking for health and fitness. How much is enough? JAMA 1991; 266:3295-3299.
  • 15. Jette MK, Sidney K, Campbell J. Effects of twelve-week walking programme on maximal and submaximal work output indices in sedentary middle-aged men and women. J Sports Med Phys Fitness 1988; 28:59-66.
  • 16. Fujino Y, Mizoue T, Tokui N, Yoshimura T. Walking exercise and its relationship to serum lipids in Japanese. J Epidemiol 2002; 12:64-69.
  • 17. Park SK, Park JH, Kwon YC, Yoon MS, Kim CS. The effect of long-term aerobic exercise on maximal oxygen consumption, left ventricular function and serum lipids in elderly women. J Physiol Anthropol 2003; 22: 11-17.
  • 18. Woolf-May K, Kearney EM, Jones DW, Davison RCR, Coleman D, et al. The effect of two different 18-week walking programmes on aerobic fitness, selected blood lipids and factor XIIa. J Sports Sci 1998; 16: 701-710.
  • 19. Barkeley Nutrition Services. Free Dietary Screeners. http://www.nutritionquest.com (accessed on January 2005).
  • 20. Astrand PO, Rodahl K. Textbook of Work Physiology: Physiological Basis of Exercise (3rd ed.), New York, McGraw-Hill, 1986.
  • 21. Borg GAV. Psychological basis of perceived exertion. Med Sci Sports Exerc 1982; 14:377-381.
  • 22. Hubinger L, Mackinnon LT, Lepre F. Lipoprotein(a) [Lp(a)] levels in middle-aged male runners and sedentary controls. Med Sci Sports Exerc 1995; 27(4): 490-496.
  • 23. Tran ZV, Weltman A. Differential effects of exercise on serum lipid and lipoprotein levels seen with changes in body weight. JAMA 1985; 254:919-924.
  • 24. Bouchard C, Despres J-P, Tremblay A. Exercise and obesity. Obesity Research 1993; 1: 133-147.
  • 25. Blair SN, Kohl HW, Paffenbarger RS, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality: A prospective study of healthy men and women. JAMA 1989; 262: 2395-2401.
  • 26. Schwartz RS, Cain KC, Shuman WP, Larson V, Stratoon JS, Beard JC, et al. Effect of intensive endurance training on lipoprotein profiles in young and older men. Metabolism 1992; 41: 649-654.
  • 27. Blair SN, Goodyear NN, Gibbons LW, Cooper KH: Physical fitness and incidence of hypertension in healthy normotensive men and women. JAMA 1984; 252: 487-490.
  • 28. Roman O, Camuzzi AL, Villalon E, Klenner C. Physical training program in arterial hypertension: A long-term prospective followup.Cardiology 1981; 67: 230-243.
  • 29. Roman O, Camuzzi AL, Villalon E, Klenner C. Physical training program in arterial hypertension. A long-term prospective followup.Cardiology 1981; 67: 230-243.
  • 30. Toth MJ, Gardner AW, Poehlman ET. Training status, resting metabolic rate, and cardiovascular disease risk in middle-aged men. Metabolism 1995; 44(3): 340-347.
  • 31. Hardman AE, Hudson A. Brisk walking and serum lipid and lipoprotein variables in previously sedentary women –effect of 12 weeks regular brisk walking followed by 12 weeks of detraining. Bri J Sports Med 1994; 28: 261-266.
  • 32. Thompson PD, Cullinane EM, Sady SP, et al. Modest changes in high-density lipoprotein concentration and metabolism with prolonged exercise training. Circulation 1988; 78: 25-34.
  • 33. Superko HR. Exercise training serum lipids, and lipoprotein particles: is there a threshold? Med Sci Sports Exerc 1991; 23(6): 677-685.
  • 34. Sacks FM, Drau VJ. Adrenergic effects on plasma lipoprotein metabolism. Speculation on mechanisms of action. Am J Med 1986;80(2A): 71-81.
  • 35. Stein RA, Michielli DW, Glantz MD, et al. Effects of different exercise training intensities on lipoprotein cholesterol fractions in healthy middle-aged men. Am Heart J 1990; 119:277-283.
  • 36. Hardman AE. Exercise in the prevention of atherosclerotic, metabolic and hypertensive diseases: A review. J Sports Sci 1996; 14:201-218.
  • 37. Boushey CJ, Beresford SA, Omenn GS, Motulky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995; 274:1049-1057.
  • 38. Fonseca V, Guba SC, Fink LM. Hyperhomocysteinemia and the endocrine system: implications for atherosclerosis and thrombosis. Endocr Rev 1999; 20:738-759.
  • 39. Vermeulen EG, Stehouwer CD, Twisk JW, et al. Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomized, placebo-controlled trial. Lancet 2000; 355:517-522.
  • 40. Chambers JC, Ueland PM, Obeid OA, et al. Improved vascular endhotelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine. Circulation 2000; 102:2479-2483.
  • 41. Herman M, Schorr H, Obeid R, et al. Homocysteine increases during endurance exercise. Clin Chem Lab Med 2003; 41:1518-1524.
Ege Tıp Dergisi-Cover
  • ISSN: 1016-9113
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1962
  • Yayıncı: Ersin HACIOĞLU
Sayıdaki Diğer Makaleler

Peutz-Jeghers sendromu ve jejunal intussussepsiyon: Bir olgunun sunumu

Özer MAKAY, M. Gökhan ÜNSAL, Erhan AKGÜN, Halit OSMANOĞLU

Sekiz haftalık iki farklı yürüme programının orta yaşlı kadınlarda aerobik kapasite, kan lipid profili ve homosistein düzeyleri üzerine etkileri

Gürbüz BÜYÜKYAZI, CANAN TIKIZ, Cevval ULMAN, Hakan TIKIZ, Bekir Sami UYANIK

131 invaziv duktal karsinom olgusunda, C-ERBB-2 artmış ekspresyonunun, histopatolojik ve immünhistokimyasal prognostik faktörlerle karşılaştırılması

Ebru ARABACI, Gülay BİLİR, Işın PAK, Ali E. DEMİRBAĞ

Adölesan sıçan beyninde antioksidan enzim aktiviteleri ve lipid peroksidasyon düzeyleri

Nazan UYSAL, Sevil GÖNENÇ, Ataç SÖNMEZ, İlkay AKSU, Ayça TOPÇU, Berkant Muammer KAYATEKİN, Osman AÇIKGÖZ

Safra kesesi kanserinde tanı ve tedavi: Kötü prognoz

MEHMET YILDIRIM, Nazif ERKAN, A. Kemal KAYAPINAR

İnvaziv mol hidatidiform: Olgu sunumu ve literatür derlemesi

Mustafa Coşan TEREK, Levent AKMAN, Osman ZEKİOĞLU, Yılmaz DİKMEN, Yıldız ERHAN, Mustafa ULUKUŞ

Akral miksoinflamatuar fibroblastik sarkom (distal ekstremitenin miksohyalin yangısal tümörü:) olgu sunumu

Enver VARDAR, Sibel DEMİR, Hakan POSTACI

Rhesus alloimmunizasyonu olan gebeliklere yaklaşım: Olgu sunumu

Sermet SAĞOL, Fuat AKERCAN, Solmaz Pınar YILDIZ, Mert KAZANDI, Teksin ÇIRPAN

Isolation of Kytococcus sedentarius from a case of pitted keraltolysis

İlgen ERTAM, Derya AYTİMUR, Seciye Eda YÜKSEL

Endometrial neoplasia with adjuvant tamoxifen treatment in breast cancer patients: Report of non-endometrioid subtypes

Yıldız ERHAN, Osman ZEKİOĞLU, Coşan Mustafa TEREK, Levent AKMAN, Aydın ÖZSARAN, Yılmaz DİKMEN, Fatih ŞENDAĞ