Romatoid elin duyusal değerlendirmesi ve manyetik rezonans görüntüleme bulguları ile ilişkisi

Amaç: Bu çalışmanın amacı, romatoid artritte (RA) elin duyusal durumunu değerlendirmek ve manyetik rezonans görüntüleme (MRG) bulguları arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Çalışmaya 33 RA tanısı almış hasta ve 33 sağlıklı kontrol grubu dahil edildi. Her iki grupta ağrı, sıcak-soğuk, dokunma, pozisyon, vibrasyon ve iki nokta diskriminasyon duyuları değerlendirildi. RA grubunda dominant el MRG çekimi yapıldı. Sinovit, tenosinovit, kemik erozyonu ve kemik ödemi OMERACT RA-MRG sistemine göre sınıflandırıldı. Bulgular: Ağrı, dokunma, sıcak-soğuk ve pozisyon duyuları RA grubunda normal olarak bulundu. Tüm hastalar vibrasyon duyusunu doğru lokalize etmesine rağmen, %60.6’sı vibrasyon duyusu şiddetinde azalma olduğunu ifade etti. İki nokta diskriminasyon değerleri RA grubunda, anlamlı düzeyde yüksek bulundu (p

Sensory examination of rheumatoid hand and the relationship with magnetic resonance imaging findings

Aim: The aim of this study was to evaluate the effect of rheumatoid arthritis (RA) on the sensory status of the hand and to determine the relationship with magnetic resonance imaging (MRI) findings. Materials and Methods: Thirty-three RA patients and controls were included in the study. Pain, hot-cold, touch, position, vibration and two point discrimination senses were evaluated in both groups. An MRI of the dominant hand was obtained in the RA group. Synovitis, tenosynovitis, bone erosion and edema were evaluated according to the OMERACT RA-MRI scoring system. Results: Pain, hot-cold, touch and position senses were normal in the RA group. Although vibration was correctly localised by all patients, 60.6% defined a decrease in intensity of vibration. Two point discrimination values were significantly higher in the RA group (p<0.001). Tenosynovitis and synovitis scores were higher in patients who described a decrease in the intensity of vibration (respectively p<0.001, p<0.05). There was a positive correlation between the two point discrimination values at the dorsal phalanx, dorsum of hand, thenar and distal palmar regions and tenosynovitis scores (p<0.05). Conclusion: In our study vibration and two point discrimination were impaired in the RA group. This can be related to nervous system involvement which can be seen in RA as an extra-articular symptom. Additionally proinflammatory cytokines which are produced by tenosynovium can affect mechanoreceptors located in the myotendinous junction leading to sensory disturbances. Hence, a detailed neurological examination is very important in RA. Furthermore, since tenosynovitis is a common pathology in RA, an MRI can be used as a supportive method in diagnosis, treatment and follow up.

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  • 1. Eberhardt KB, Fex E. Functional impairment and disability in early rheumatoid arthritis-development over 5 years. J Rheumatol 1995; 22(6):1037-42.
  • 2. Lefevre-Colau MM, Poiraudeau S, Fermanian J, et al. Responsiveness of the Cochin rheumatoid hand disability scale after surgery. Rheumatology 2001;40(8):843-50.
  • 3. Matteson EL. Extraarticular manifestations of rheumatoid arthritis and systemic involvement. Hochberg MK, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH (eds). Volume 1, 3rd ed., 2003:781-92.
  • 4. Agarwal V, Singh R, Wiclaf S, et al. A clinical, electrophysiological, and pathological study of neuropathy in rheumatoid arthritis. Clin Rheumatol 2008;27(7):841-4.
  • 5. Chamberlain MA, Bruckner FE. Rheumatoid neuropathy. Clinical and electrophysiological features. Ann Rheum Dis 1979;29(6):609-16.
  • 6. Toussirot E, Serratrice G, Valentin P. Autonomic nervous system involvement in rheumatoid arthritis. 50 cases. Rheumatol 1993;20(9):1508-14.
  • 7. Calder KM, Martin A, Lydiate J, MacDermid JC, Galea V, MacIntyre NJ. Sensory nerve action potentials and sensory perception in women with arthritis of the hand. J NeuroEng Rehabil 2012;9(1):27-37.
  • 8. Muramatsu K, Tanaka H, Taguchi T. Peripheral neuropathies of the forearm and hand in rheumatoid arthritis: diagnosis and options for treatment. Rheumatol Int 2008;28(10):951-7.
  • 9. Dellhag B, Hosseini N, Bremell T, Inqvarsson PE. Disturbed grip function in women with rheumatoid arthritis. J Rheumatol 2001;28(12):2624-33.
  • 10. Dellhag B, Burckhardt CS. Predictors of hand function in patients with rheumatoid arthritis. Arthritis Care Res 1995;8(1):16-20.
  • 11. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31(3):315-24.
  • 12. Johnson KS. Upper extremity functional capacity evaluation. Hunter JM, Mackin EJ, Callahan AD (eds). Rehabilitation of the Hand: Surgery and Therapy. Volume 2, 4th Edition; St Louis: Mosby; 1995:1739-74.
  • 13. Waylett-Rendall J. Sensibility evaluation and rehabilitation. Orthop Cl North Am 1988;19(1):43-56.
  • 14. Gilman S. Joint position sense and vibration sense: anatomical organisation and assessment. J Neurol Neurosurg Psychiatry 2002;73(5):473-7.
  • 15. Callahan AD. Sensibility assessment: prerequisities and techniques for nevre lesions in continuity and nevre lacerations. Hunter JM, Mackin EJ, Callahan AD (eds). Rehabilitation of the Hand: Surgery and Therapy. Volume 1, 4th ed. St Louis: Mosby; 1995:129-52.
  • 16. Swanson AB, Swanson GG, Hagert CG. Evaluation of impairment of hand function. Hunter JM, Mackin EJ, Callahan AD (eds). Rehabilitation of the Hand: Surgery and Therapy. Volume 2, 4th Edition. St Louis: Mosby; 1995:1839-96.
  • 17. Boutry N, Hachulla E, Flipo RM, Cortet B, Cotten A. MR imaging findings in hands in early rheumatoid arthritis: Comparison with those in systemic lupus erythematosus and primary Sjogren syndrome. Radiology 2005;236(2):593-600.
  • 18. McQueen FM, Stewart N, Crabbe J, et al. Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months after symptom onset. Ann Rheum Dis 1998;57(6):350-6.
  • 19. Alamanos Y, Voulgari PV, Drosos AA. Incidence and prevalence of rheumatoid arthritis based on the 1987 American College of Rheumatology criteria: A systematic review. Semin Arthritis Rheum 2006;36(3):182-8.
  • 20. Hakkinen A, Kautiainen H, Hannonen P, Ylinen J, Makinen H, Sokka T. Muscle strength, pain and disease activity explain individual subdimensions of the Health Assessment Questionnaire disability index, especially in women with rheumatoid arthritis. Ann Rheum Dis 2006;65(1):30-4.
  • 21. Stucki G, Bruhlmann P, Stucki S, Michel BA. Isometric muscle strength is an indicator of self -reported physical functional disability in patients with rheumatoid arthritis. Br J Rheumatol 1998;37(6):643-8.
  • 22. Lanzillo B, Pappone N, Crisci C, di Girolamo C, Massini R, Caruso G. Subclinical peripheral nerve involvement in patients wit h rheumatoid arthritis. Arthritis Rheum 1998;41(7):1196-202
  • 23. Peyronnard JM, Charron L, Beaudet F, Couture F. Vasculitis neuropathy in rheumatoid disease and Sjögren syndrome. Neurology 1982; 32 (8):839-45.
  • 24. Bekkelund SI, Mellgren SI, Prøven A, Husby G. Quantified neurological examination with emphasis on motor and sensory functions in patients with rheumatoid arthritis and controls. Br J Rheumatol. 1996; 35(11):1116-21.
  • 25. Weller RO, Bruckner FE, Chamberlain MA. Rheumatoid neuroropathy: A histopathological and electrophysiological study. J Neurol Neurosurg Psychiatry 1970;33(5):592-604.
  • 26. Good AF, Cristopher RP, Koepke GH, Bender LF, Tarter ME. Peripheral neuropathy associated with rheumatoid arthritis: A clinical and electrodiagnostic study of 70 consecutive rheumatoid arthritis patients. Ann Intern Med 1965;63(1):87-99.
  • 27. Helliwell PS. Normal vibration perception thresholds in rheumatoid arthritis-evidence against the neurogenic theory of articular stiffness. Clin Rheumatol 1994;13(1):51-3.
  • 28. Zimmy ML, DePaolo C, Dabezies E. Mechanoreceptors in the flexor tendons of the hand. J Hand Surg Br 1989;14(2):229-31.
  • 29. Jozsa L, Balint J, Kannus P, Jarvinen M, Lehto M. Mechanoreceptors in human myotendinous junction. Muscle Nerve 1993;16(5):453-7.
  • 30. Ferrell WR, Craske B. Contribution of joint and muscle afferents to position sense at the human proximal interphalangeal joint. Exp Physiol 1992;77(2):331-42.
  • 31. Ferrell WR, Crighton A, Sturrock R. Position sense at the proximal interphalangeal joint is distorted in patients with rheumatoid arthritis of finger joints. Exp Physiol 1992;77(5):675-80.
  • 32. Jain A, Nanchahal J, Troeberg L, Green P, Brennan F. Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritis. Arthritis Rheum 2001;44(8):1754-60.
  • 33. Aeberli D, Oertle S, Mauron H, Reichenbach S, Jordi B, Villiger PM. Inhibition of the TNF-pathway: use of infliximab and etanercept as remission-inducing agents in cases of therapy-resistant chronic inflammatory disorders. Swiss Med Wkly 2002;132(29-30):414-22.
  • 34. Pay S, Erdem H, Serdar M, Dinç A, Şimşek I, Turan M. Comparison of synovial MMP-1 and TIMP-1 levels in patients with various inflammatory arthritides: Is there any difference between rheumatoid arthritis, Behcet’s disease and familial Mediterranean fever? Clin Rheumatol 2002;21(6):511-5.
Ege Tıp Dergisi-Cover
  • ISSN: 1016-9113
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1962
  • Yayıncı: Ersin HACIOĞLU
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