Overin malign mikst müllerian tümörleri: Üç olgu sunumu
Overin malign mikst müllerian tümörleri (MMMT) nadir görülen, histolojik olarak malign epitelyal ve mezenkimal komponent içeren oldukça agresif neoplazmlardır. Bu tümörler tüm over malignitelerinin %1'inden azını oluşturur ve daha çok düşük pariteli ve postmenapozal kadınlarda görülür. Yapılan çalışmalar en önemli prognostik faktörün tanı konduğu sıradaki klinik evrenin olduğunu vurgulamaktadır. İleri evrelerde olan ilk iki olgumuz takiplerinin ilk bir yılı içinde kaybedilirken evre IA olan üçüncü olgumuz yedi yıldan beri yaşamını sürdürmektedir. Olgu sayımız çok az olmasına rağmen overin MMMT'lerinde evrenin en önemli prognostik faktör olduğu sonucuna vardık.
Ovarian malign mixed mullerian tumors: Report of three cases
Ovarian MMMT is a rare, highly aggressive neoplasm comprising histologically of both epithelial and mesenchymal components. This tumor constitutes less than 1% of all ovarian malignancies and tend to occur in low parity women of postmenapausal status. In recent studies, the most important prognostic factor that has been demostrated is the clinical stage at the time of diagnosis. Although our two patients who were in advanced stages died in one year, the third patient was in stage IA and she is still alive and on follow-up for seven years. Although the number of the cases presented here is small, we demonstrated that the stage was a significant prognostic factor in ovarian MMMT.
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- 1. Dehner LP, Norris HJ, Taylor HB. Carcinosarcomas and mixed mesodermal tumors of the ovary. Cancer 1971 ;27: 207-216.
- 2. Morrovv CP, d'Ablaing G, Brady LW, Blessing JA. A clinical and pathologic study of 30 cases of malignant mixed müllerian epithelial and mesenchymal ovarian tumors: a gynecologic oncology group study. Gynecol Oncol 1984; 18: 278-292.
- 3. Kurman RJ.Blaustein's Pathology of the Female Genital Tract.
- 4. edition, 1994; 749-750. 4. Sood AK, Sorosky Jl, Gelder MS, et al. Primary ovarian sarcoma: Analysis of prognostic variables and the role of surgical cytoreduction. Cancer 1998; 82: 1731-1737.
- 5. Scully RE, Young RH, Clement PB. Tumrs of the ovary, Maldeveloped Gonads, Fallopian Tube and Broad Ligament. Atlas of Tumor Pathology AFIP 1996: 128-131.
- 6. Chang J, Sharp JC, A'Hern RP et al. Carcinosarcoma of the ovary: incidence, prognosis, treatment and survival of patients. Ann Oncol 1995; 6:755-758.
- 7. Ariyoshi K, Kavvauchi S, Kaku T, et al. Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases. Histopathology 2000: 37:427-436.
- 8. Dictor M. Maiign mixed mesodermal tumor of the ovary. A report of 22 cases. Obstet Gynecol 1995; 65: 720-724.
- 9. Peters WA III, Kumar NB, Flemign WP, et al. Prognostic features of sarcomas and mixed tumors of th endometrium. Obstet Gynecol 1984; 63: 550-556.
- 10. Silverberg SG, Majör FJ, Blessing JA, et al. Carcinosarcoma (Maiign Mixed Mesodermal Tumor) of the uterus: A Gynecologic Oncology Group pathologic study of 203 cases. int J Gynecol Pathol 1990: 9; 1-19.
- 11. Costa MJ, Khan R, Judd R. Carcinosarcoma (Maiign Mixed Mesodermal Tumor) of th uterus and ovary. Arch Pathol Lab Med 1991: 115;583-590.
- 12. Dinh TV, Slavin R, Bhavagan BS, et al. Mixed mesodermal tumors of the ovary: A clinicopathologic study of 14 cases. Obstet Gynecol 1988: 72; 409-412.
- 13. Meis JM, Lavvrence WD. The immunohistochemical profile of maiign mixed müllerian tumor: Overlap with endometrial carcinoma. Am J Clin Pathol 1990: 94; 1-7.
- 14. George E, Manivel JC, Dehner LP, et al. Malignant mixed mülierian tumors: An immunohistochemica! study of 4/ cases vvith histogenetic cosiderations and clinical correlation. Hum Pathol 1991:22; 215-223.
- 15. De Brito P, Silverberg S, Orenstein JM. Carcinosarcoma(IVİalign Mixed Müüerian (mesodermal) Tumor) of the Femaie Genital Tract: Immunohistochemical and ultrastructural analysis of 28 cases. Hum Pathol 1993: 24; 132-142.
- 16. Barvvick KW, Li Volsi VA. Malignant rnixed mesodermal tumors of the ovary. A clinicopathologic assessment of 12 cases. Am J Surg Pathol 1980: 4; 37-42.